STRUCTURAL REQUIREMENTS FOR THE DEVELOPMENT OF POTENT N-METHYL-D-ASPARTIC ACID (NMDA) RECEPTOR ANTAGONISTS

被引：49
作者：
BIGGE, CF
机构：
来源：
BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 08期
关键词：
D O I：
10.1016/0006-2952(93)90294-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1547 / 1561
页数：15
相关论文
共 84 条
  • [1] SYNTHESIS AND NMDA ANTAGONISTIC PROPERTIES OF THE ENANTIOMERS OF 4-(3-PHOSPHONOPROPYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP) AND OF THE UNSATURATED ANALOG (E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP-ENE)
    AEBISCHER, B
    FREY, P
    HAERTER, HP
    HERRLING, PL
    MUELLER, W
    OLVERMAN, HJ
    WATKINS, JC
    [J]. HELVETICA CHIMICA ACTA, 1989, 72 (05) : 1043 - 1051
  • [2] N-METHYL-D-ASPARTATE ANTAGONISTS - READY FOR CLINICAL-TRIAL IN BRAIN ISCHEMIA
    ALBERS, GW
    GOLDBERG, MP
    CHOI, DW
    [J]. ANNALS OF NEUROLOGY, 1989, 25 (04) : 398 - 403
  • [3] KINETIC-ANALYSIS OF ANTAGONIST ACTION AT N-METHYL-D-ASPARTIC ACID RECEPTORS - 2 BINDING-SITES EACH FOR GLUTAMATE AND GLYCINE
    BENVENISTE, M
    MAYER, ML
    [J]. BIOPHYSICAL JOURNAL, 1991, 59 (03) : 560 - 573
  • [4] EXPLORATION OF N-PHOSPHONOALKYL-SPACED, N-PHOSPHONOALKENYL-SPACED, AND N-(PHOSPHONOALKYL)PHENYL-SPACED ALPHA-AMINO-ACIDS AS COMPETITIVE N-METHYL-D-ASPARTIC ACID ANTAGONISTS
    BIGGE, CF
    JOHNSON, G
    ORTWINE, DF
    DRUMMOND, JT
    RETZ, DM
    BRAHCE, LJ
    COUGHENOUR, LL
    MARCOUX, FW
    PROBERT, AW
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (08) : 1371 - 1384
  • [5] BIGGE CF, 1992, MULTIPLE SIGMA PCP R, P1
  • [6] CARTER CJ, 1990, J PHARMACOL EXP THER, V253, P475
  • [7] PROTEIN-KINASE-C REDUCES MG2+ BLOCK OF NMDA-RECEPTOR CHANNELS AS A MECHANISM OF MODULATION
    CHEN, L
    HUANG, LYM
    [J]. NATURE, 1992, 356 (6369) : 521 - 523
  • [8] EVALUATION OF A COMPETITIVE NMDA ANTAGONIST (D-CPPENE) IN FELINE FOCAL CEREBRAL-ISCHEMIA
    CHEN, M
    BULLOCK, R
    GRAHAM, DI
    FREY, P
    LOWE, D
    MCCULLOCH, J
    [J]. ANNALS OF NEUROLOGY, 1991, 30 (01) : 62 - 70
  • [9] SEPARATION OF ALPHA-1 ADRENERGIC AND N-METHYL-D-ASPARTATE ANTAGONIST ACTIVITY IN A SERIES OF IFENPRODIL COMPOUNDS
    CHENARD, BL
    SHALABY, IA
    KOE, BK
    RONAU, RT
    BUTLER, TW
    PROCHNIAK, MA
    SCHMIDT, AW
    FOX, CB
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (10) : 3085 - 3090
  • [10] EXCITATORY AMINO-ACID RECEPTORS AND SYNAPTIC PLASTICITY
    COLLINGRIDGE, GL
    SINGER, W
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (07) : 290 - 296
123456789