CHRONIC NICOTINE-INDUCED CHANGES IN DOPAMINERGIC SYSTEM - EFFECT ON BEHAVIORAL-RESPONSE TO DOPAMINE AGONIST

被引：7
|
作者：
SERSHEN, H
HASHIM, A
HARSING, L
LAJTHA, A
机构：
[1] Center for Neurochemistry, N. S. Kline Institute, Orangeburg
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 02期
关键词：
NICOTINE; DOPAMINERGIC SYSTEM; D2-AUTORECEPTOR; APOMORPHINE; LOCOMOTOR ACTIVITY;
D O I：
10.1016/0091-3057(91)90225-Q
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The effect of chronic nicotine on dopamine-agonist-mediated locomotor activity response was measured in BALB/cBy and C57BL/6 mice. Mice were injected twice daily for 10 days with 1.2 mg/kg SC (-)-nicotine di-(+)tartrate. Subsequent locomotor activity response to apomorphine (1 mg/kg SC) was measured. Apomorphine induced hypomotility in both strains of mice, with the BALB/cBy mice showing a greater hypomotility compared to the C57BL/6 mice. This response to apomorphine was attenuated in both strains of mice that were treated previously with repeated injections of nicotine. The results suggest that chronic nicotine may induce changes in the dopaminergic system, which is reflected in altered behavioral response to a dopamine agonist.
引用
收藏
页码：545 / 547
页数：3
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