DETERMINATION OF KAPPA AND LAMBDA LIGHT-CHAINS IN SERUM IMMUNOGLOBULIN-G, IMMUNOGLOBULIN-A AND IMMUNOGLOBULIN-M

被引:21
作者
HARALDSSON, A [1 ]
KOCKJANSEN, MJH [1 ]
JAMINON, M [1 ]
VONECKARTS, PBJM [1 ]
DEBOO, T [1 ]
WEEMAES, CMR [1 ]
BAKKEREN, JAJM [1 ]
机构
[1] UNIV HOSP NIJMEGEN,DEPT MED STAT,6500 HB NIJMEGEN,NETHERLANDS
关键词
IMMUNOGLOBULIN LIGHT CHAINS; KAPPA LAMBDA LIGHT CHAIN RATIO;
D O I
10.1177/000456329102800507
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
An enzyme-linked immunosorbent assay is described for measuring kappa and lambda light chains within each of the serum immunoglobulin classes G, A and M. The detection limit was 0.06 U/L for total IgG, IgG kappa and IgG lambda, 0.2 U/L for total IgA, IgA kappa and IgA lambda and 0.5 U/L for total IgM, IgM kappa and IgM lambda. The concentrations of kappa plus lambda light chains from the three different immunoglobulins correlated well within those of total immunoglobulin G, A and M as measured by enzyme-linked immunosorbent assay or by immunonephelometry. Adult values for the kappa/lambda light chain ratio were found to be 2.0 for IgG kappa/lambda, 1.1 for IgA kappa/lambda and 1.7 for IgM kappa/lambda.
引用
收藏
页码:461 / 466
页数:6
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