THE MOLECULAR MECHANISM BY WHICH INSULIN STIMUALTES GLYCOGEN-SYNTHESIS IN MAMMALIAN SKELETAL-MUSCLE

被引：501

作者：

DENT, P ^{[1
]}

LAVOINNE, A ^{[1
]}

NAKIELNY, S ^{[1
]}

CAUDWELL, FB ^{[1
]}

WATT, P ^{[1
]}

COHEN, P ^{[1
]}

机构：

[1] UNIV DUNDEE,DEPT ANAT & PHYSIOL,DUNDEE DD1 4HN,SCOTLAND

来源：

NATURE | 1990年 / 348卷 / 6299期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/348302a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ability of insulin to promote the phosphoryl-ation of some proteins and the dephosphorylation of others is paradoxical. An insulin-stimulated protein kinase is shown to activate the type-1 protein phosphatase that controls glycogen metabolism, by phosphorylating its regulatory subunit at a specific serine. Furthermore, the phosphorylation of this residue is stimulated by insulin in vivo. Increased and decreased phosphorylation of proteins by insulin can therefore be explained through the same basic underlying mechanism. © 1990 Nature Publishing Group.

引用

页码：302 / 308

页数：7

共 50 条

[41] PRIMARY-STRUCTURE REQUIREMENTS FOR INHIBITION BY THE HEAT-STABLE INHIBITOR OF THE CAMP-DEPENDENT PROTEIN-KINASE [J].

SCOTT, JD ;

GLACCUM, MB ;

FISCHER, EH ;

KREBS, EG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1613-1616

[42]

STEWART AA, 1981, EUR J BIOCHEM, V115, P197

[43] THE PROTEIN PHOSPHATASES INVOLVED IN CELLULAR-REGULATION - PURIFICATION AND CHARACTERIZATION OF THE GLYCOGEN-BOUND FORM OF PROTEIN PHOSPHATASE-1 FROM RABBIT SKELETAL-MUSCLE [J].

STRALFORS, P ;

HIRAGA, A ;

COHEN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 149 (02) :295-303

[44] INSULIN-STIMULATED MAP-2 KINASE PHOSPHORYLATES AND ACTIVATES RIBOSOMAL-PROTEIN S6 KINASE-II [J].

STURGILL, TW ;

RAY, LB ;

ERIKSON, E ;

MALLER, JL .

NATURE, 1988, 334 (6184) :715-718

[45]

TOTH B, 1988, J BIOL CHEM, V263, P14061

[46] EFFECTS OF INSULIN ON THE PHOSPHATE CONTENT AND KINETICS OF GLYCOGEN-SYNTHASE IN PERFUSED RAT HINDLIMB MUSCLE [J].

UHING, RJ ;

SHIKAMA, H ;

EXTON, JH .

FEBS LETTERS, 1981, 134 (02) :185-188

[47] INSULIN-MEDIATED EFFECT ON THE ACTIVITY OF UDPG-GLYCOGEN TRANSGLUCOSYLASE OF MUSCLE [J].

VILLARPALASI, C ;

LARNER, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 39 (01) :171-173

[48] IDENTIFICATION OF PHOSPHORYLATION SITES IN PEPTIDES USING A GAS-PHASE SEQUENCER [J].

WANG, YH ;

FIOL, CJ ;

DEPAOLIROACH, AA ;

BELL, AW ;

HERMODSON, MA ;

ROACH, PJ .

ANALYTICAL BIOCHEMISTRY, 1988, 174 (02) :537-547

[49]

ZHANG JN, 1989, J BIOL CHEM, V264, P17513

[50] THE INSULIN-RECEPTOR - STRUCTURE AND FUNCTION [J].

ZICK, Y .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1989, 24 (03) :217-269

← 1 2 3 4 5 →