Stem cell therapy in amyotrophic lateral sclerosis

被引：2

作者：

Hsueh, Kuo-Wei ^{[1
]}

Hsieh, An-Chang ^{[2
]}

Harn, Horng-Jyh ^{[3
,4
]}

Lin, Shinn-Zong ^{[2
,5
,6
]}

机构：

[1] China Med Univ, PhD Program Aging, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[2] China Med Univ, Grad Inst Immunol, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Pathol, Taichung, Taiwan

[4] China Med Univ, Dept Med, Taichung, Taiwan

[5] China Med Univ Hosp, Neuropsychiat Ctr, Taichung, Taiwan

[6] China Med Univ, Beigan Hosp, Dept Neurosurg, Yunlin, Taiwan

来源：

BIOMEDICINE-TAIWAN | 2012年 / 2卷 / 02期

关键词：

amyotrophic lateral sclerosis; motor neurons; superoxide dismutase 1;

D O I：

10.1016/j.biomed.2012.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyotrophic lateral sclerosis (ALS) is a rare and lethal neurodegenerative disease for which there is no effective medical treatment. Although riluzole, an N-methyl-D-aspartate receptor antagonist, has been shown to be reasonably safe for patients with ALS, the drug has been demonstrated to prolong median survival by only 2-5 months. There is mounting evidence that stem cell-based gene therapy is a promising treatment modality for patients with ALS. In this review, we focus on the types, sources, and doses of stem cells that have been shown to be effective for ALS patients, the differences in cytokines or chemokines secreted from these various stem cells, and the immune-modulation activity of stem cells as treatment for ALS. Copyright (C) 2012, China Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：58 / 63

页数：6

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