SIMPLIFIED PET QUANTITATION OF MYOCARDIAL GLUCOSE-UTILIZATION

被引:0
作者
NAKAGAWA, K
NAMBA, H
IYO, M
FUKUSHI, K
IRIE, T
YAMANOUCHI, M
SHIKAMA, N
HIMI, T
YOSHIDA, K
MASUDA, Y
机构
[1] CHIBA UNIV,DEPT INTERNAL MED 3,CHIBA,JAPAN
[2] NATL INST RADIOL SCI,DIV CLIN SCI,CHIBA,JAPAN
[3] CHIBA CANC CTR HOSP,DEPT NEUROSURG,CHIBA,JAPAN
[4] NATL CTR NEUROL & PSYCHIAT,NATL INST MENT HLTH,CHIBA,JAPAN
关键词
MYOCARDIUM; ORAL GLUCOSE LOAD; POSITRON EMISSION TOMOGRAPHY; CARBON-14-DEOXYGLUCOSE; FLUORINE-18-FDG;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of this study was to validate experimentally a simple method to quantify tissue glucose utilization with the brain reference index (BRI) using C-14-deoxyglucose and assess its clinical feasibility for myocardial PET. Methods: To validate the BRI method, glucose utilization in myocardial and skeletal muscle was studied in rats with C-14-deoxyglucose after increasing doses of oral glucose loading. To assess clinical feasibility of the method, the BRI was applied to nine patients undergoing myocardial PET and compared to rMGU measured by the deoxyglucose model of Sokoloff et al. and by Patlak graphical analysis. The normal range of myocardial FDG uptake expressed as the BRI was estimated with four normal volunteers. Results: In skeletal muscle, a dose-dependent increase of glucose utilization was observed during oral glucose loading with doses up to 4 mg/g. In the myocardium, glucose utilization increased with a glucose loading dose of up to 1 mg/g without increasing further at greater glucose doses. Ratios of maximal glucose utilization in glucose-loaded rats to 19-hr fasted rats (controls), expressed as the BRI for left and right ventricular myocardium and skeletal muscle were 4.16, 3.74 and 7.39, respectively. Glucose utilization of right ventricular myocardium was approximately 70% of left ventricular myocardium for all glucose-loaded conditions. For patients, the BRI correlated with rMGU; four of these patients had a constant plasma glucose concentration. Conclusion: Myocardial BRI is a sensitive indicator of rMGU that does not require dynamic data acquisition or constant plasma glucose concentrations.
引用
收藏
页码:2094 / 2102
页数:9
相关论文
共 50 条
  • [21] POSITRON EMISSION TOMOGRAPHIC MEASUREMENTS OF CEREBRAL GLUCOSE-UTILIZATION USING [1-C-11]D-GLUCOSE
    BLOMQVIST, G
    STONEELANDER, S
    HALLDIN, C
    ROLAND, PE
    WIDEN, L
    LINDQVIST, M
    SWAHN, CG
    LANGSTROM, B
    WIESEL, FA
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (04) : 467 - 483
  • [22] A SIMPLE METHOD FOR MEASURING GLUCOSE-UTILIZATION OF INSULIN-SENSITIVE TISSUES BY USING THE BRAIN AS A REFERENCE
    NAMBA, H
    NAKAGAWA, K
    IYO, M
    FUKUSHI, K
    IRIE, T
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1994, 21 (03): : 228 - 231
  • [23] NONINVASIVE METHOD TO OBTAIN INPUT FUNCTION FOR MEASURING TISSUE GLUCOSE-UTILIZATION OF THORACIC AND ABDOMINAL ORGANS
    OHTAKE, T
    KOSAKA, N
    WATANABE, T
    YOKOYAMA, I
    MORITAN, T
    MASUO, M
    IIZUKA, M
    KOZENI, K
    MOMOSE, T
    OKU, S
    NISHIKAWA, J
    SASAKI, Y
    IIO, M
    JOURNAL OF NUCLEAR MEDICINE, 1991, 32 (07) : 1432 - 1438
  • [24] AUTORADIOGRAPHIC ASSESSMENT OF PINEAL-GLAND GLUCOSE-UTILIZATION AND CAPILLARY-PERMEABILITY IN THE UNANESTHETIZED RAT
    CICCIARELLO, R
    DAVELLA, D
    DEBLASI, F
    PRINCI, P
    RUSSO, F
    PALAZZOLO, A
    CANALE, F
    ALBIERO, F
    MESITI, M
    GERMANO, A
    PENSABENE, V
    SCANARINI, M
    CHILDS NERVOUS SYSTEM, 1990, 6 (04) : 222 - 224
  • [25] CEREBRAL GLUCOSE-UTILIZATION MEASURED WITH POSITRON EMISSION TOMOGRAPHY (PET) AS AN INDEX FOR NEUROLOGICAL FUNCTIONING IN LONG-TERM SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL)
    SUHONENPOLVI, H
    SALMI, TT
    KORHONEN, T
    NORVASUOHEILA, MK
    RUOTSALAINEN, U
    RIIKONEN, R
    BERGMAN, J
    HAAPARANTA, M
    NUUTILA, P
    VALAVAARA, R
    SONNINEN, P
    WEGELIUS, U
    INTERNATIONAL JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, 1995, 2 (01): : 63 - 71
  • [26] GLUTAMATE UPTAKE INTO ASTROCYTES STIMULATES AEROBIC GLYCOLYSIS - A MECHANISM COUPLING NEURONAL-ACTIVITY TO GLUCOSE-UTILIZATION
    PELLERIN, L
    MAGISTRETTI, PJ
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (22) : 10625 - 10629
  • [27] CEREBRAL METABOLIC PATTERN IN OBSESSIVE-COMPULSIVE DISORDER - ALTERED INTERCORRELATIONS BETWEEN REGIONAL RATES OF GLUCOSE-UTILIZATION
    HORWITZ, B
    SWEDO, SE
    GRADY, CL
    PIETRINI, P
    SCHAPIRO, MB
    RAPOPORT, JL
    RAPOPORT, SI
    PSYCHIATRY RESEARCH-NEUROIMAGING, 1991, 40 (04) : 221 - 237
  • [28] Mechanism of Reduced Myocardial Glucose Utilization During Acute Hypertriglyceridemia in Rats
    Menard, Sebastien L.
    Ci, Xiuli
    Frisch, Frederique
    Normand-Lauziere, Francois
    Cadorette, Jules
    Ouellet, Rene
    Van Lier, Johannes E.
    Benard, Francois
    Bentourkia, M'hamed
    Lecomte, Roger
    Carpentier, Andre C.
    MOLECULAR IMAGING AND BIOLOGY, 2009, 11 (01) : 6 - 14
  • [29] Absolute Quantitation of Myocardial Blood Flow in Human Subjects With or Without Myocardial Ischemia Using Dynamic Flurpiridaz F 18 PET
    Packard, Rene R. S.
    Huang, Sung-Cheng
    Dahlbom, Magnus
    Czemin, Johannes
    Maddahi, Jamshid
    JOURNAL OF NUCLEAR MEDICINE, 2014, 55 (09) : 1438 - 1444
  • [30] Single time point quantitation of cerebral glucose metabolism by FDG-PET without arterial sampling
    Cumming, Paul
    Dias, Andre H.
    Gormsen, Lars C.
    Hansen, Allan K.
    Alberts, Ian
    Rominger, Axel
    Munk, Ole L.
    Sari, Hasan
    EJNMMI RESEARCH, 2023, 13 (01)