Cost-effectiveness analysis of antiretroviral therapy in a cohort of HIV-infected patients starting first-line highly active antiretroviral therapy during 6 years of observation

被引:3
作者
Maggiolo, Franco [1 ]
Colombo, Giorgio L. [2 ,3 ]
Di Matteo, Sergio [3 ]
Bruno, Giacomo M. [3 ]
Astuti, Noemi [1 ]
Di Filippo, Elisa [1 ]
Masini, Giulia [1 ]
Bernardini, Claudia [1 ]
机构
[1] Azienda Osped Papa Giovanni XXIII, Div Infect Dis, Bergamo, Italy
[2] Univ Pavia, Dept Drug Sci, Pavia, Italy
[3] SAVE Anal Valutaz Econ, Via Previati 74, I-20149 Milan, Italy
关键词
cost-effectiveness; quality-adjusted life years; highly active antiretroviral therapy; single-tablet regimen;
D O I
10.2147/PROM.S63586
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objectives: Costs may play a role in deciding how and when to start highly active antiretroviral therapy (HAART) in a naive patient. The aim of the present study was to assess the cost-effectiveness of treatment with HAART in a large clinical cohort of naive adults to determine the potential role of single-tablet regimens in the management of patients with human immunodeficiency virus (HIV). An incremental cost-effectiveness ratio analysis was performed, including a quality-adjusted life year approach. Results: In total, 741 patients (females comprising 25.5%) were retrospectively included. The mean age was 39 years, the mean CD4 cell count was 266 cells/mu L, and the mean viral load was 192,821 copies/mL. The most commonly used backbone was tenofovir + emtricitabine (77.6%); zidovudine + lamivudine was used in 10%, lamivudine + abacavir in 3%, and other nucleoside reverse transcriptase inhibitor (NRTI) or NRTI-free regimens in 9.4% of patients. NNRTIs were used in 52.8% of cases, boosted protease inhibitors in 44.1%, and unboosted protease inhibitors and integrase inhibitors in 0.7% and 2.4%, respectively. Starting therapy at CD4>500 cells/mu L and CD4 351-500 cells/mu L rather than at,201 cells/mu L was the more cost-effective approach. The same consideration was not true comparing current indications with the possibility to start HAART at any CD4 value (eg,>500 cells per mu L); in this case, the incremental cost-effectiveness ratio value was (sic) 199,130 per quality-adjusted life year gained, a higher value than the one suggested in guidelines. The single-tablet regimen (STR) invariably dominated any other therapeutic approach. Sensitivity analysis was performed, and starting right away with an STR was cost-effective even when compared with therapeutic strategies contemplating STR as simplification. Conclusion: By integrating clinical data with economic variables, our study offers an estimate of the cost-effectiveness of the various first-line treatment strategies for patients infected with HIV and provides significant evidence to be used in future prospective pharmacoeconomic evaluations.
引用
收藏
页码:53 / 60
页数:8
相关论文
共 29 条
[1]  
Airoldi M, 2010, PATIENT PREFER ADHER, V4, P115
[2]  
Antinori A, 2011, NEW MICROBIOL, V34, P109
[3]   Medication persistence in the treatment of HIV infection: a review of the literature and implications for future clinical care and research [J].
Bae, Jason W. ;
Guyer, William ;
Grimm, Kristy ;
Altice, Frederick L. .
AIDS, 2011, 25 (03) :279-290
[4]  
Cohen MS, 2011, NEW ENGL J MED, V365, P493, DOI [10.1056/NEJMoa1105243, 10.1056/NEJMoa1600693]
[5]   Economic evaluation of initial antiretroviral therapy for HIV-infected patients: an update of Italian guidelines [J].
Colombo, Giorgio L. ;
Di Matteo, Sergio ;
Antinori, Andrea ;
Medaglia, Massimo ;
Murachelli, Silvia ;
Rizzardini, Giuliano .
CLINICOECONOMICS AND OUTCOMES RESEARCH, 2013, 5 :489-496
[6]   Cost analysis of initial highly active antiretroviral therapy regimens for managing human immunodeficiency virus-infected patients according to clinical practice in a hospital setting [J].
Colombo, Giorgio L. ;
Castagna, Antonella ;
Di Matteo, Sergio ;
Galli, Laura ;
Bruno, Giacomo ;
Poli, Andrea ;
Salpietro, Stefania ;
Carbone, Alessia ;
Lazzarin, Adriano .
THERAPEUTICS AND CLINICAL RISK MANAGEMENT, 2014, 10 :9-15
[7]   Antiretroviral therapy in HIV-infected patients: a proposal to assess the economic value of the single-tablet regimen [J].
Colombo, Giorgio L. ;
Di Matteo, Sergio ;
Maggiolo, Franco .
CLINICOECONOMICS AND OUTCOMES RESEARCH, 2013, 5 :59-68
[8]  
Department of Health and Human Services, GUIDELINES USE ANTIR
[9]   Prevalence and correlates of nonadherence to antiretroviral therapy in a population of HIV patients using Medication Event Monitoring System® [J].
Deschamps, AE ;
De Graeve, V ;
Van Wijngaerden, E ;
De Saar, V ;
Vandamme, AM ;
Van Vaerenbergh, K ;
Ceunen, H ;
Bobbaers, H ;
Peetermans, WE ;
De Vleeschouwer, PJ ;
De Geest, S .
AIDS PATIENT CARE AND STDS, 2004, 18 (11) :644-657
[10]   Does combining antiretroviral agents in a single dosage form enhance quality of life of HIV/AIDS patients? A cost-utility study [J].
Ganguli, Arijit ;
Wang, Junling ;
Gourley, Dick R. .
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY, 2012, 8 (02) :157-165