ONCOGENES IN RADIORESISTANT, NONCANCEROUS SKIN FIBROBLASTS FROM A CANCER-PRONE FAMILY

被引：117

作者：

CHANG, EH

PIROLLO, KF

ZHI, QZ

CHEUNG, HY

LAWLER, EL

GARNER, R

WHITE, E

BERNSTEIN, WB

FRAUMENI, JW

BLATTNER, WA

机构：

[1] WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307

[2] NCI,EPIDEMIOL BRANCH,BETHESDA,MD 20892

来源：

SCIENCE | 1987年 / 237卷 / 4818期

关键词：

D O I：

10.1126/science.3616624

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Li-Fraumeni syndrome is manifested in a variety of neoplasms that are transmitted in a dominantly inherited pattern. The noncancerous skin fibroblasts of family members exhibit a unique characteristic of being resistant to the killing effect of ionizing radiation. A three- to eightfold elevation in expression of c-myc and an apparent activation of c-raf-l gene have been observed in these noncancerous skin fibroblasts. These results may provide insight into the heritable defect underlying die familial predisposition to a variety of cancers.

引用

页码：1036 / 1039

页数：4

共 35 条

[1] BIOCHEMICAL AND IMMUNOLOGICAL CHARACTERIZATION OF POLYPROTEINS CODED FOR BY THE MCDONOUGH, GARDNER-ARNSTEIN, AND SNYDER-THEILEN STRAINS OF FELINE SARCOMA-VIRUS [J].