MicroRNAs in Experimental Models of Movement Disorders

被引：3

作者：

Lee, Soon-Tae ^{[1
]}

Kim, Manho ^{[1
]}

机构：

[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, 101 Daehak Ro, Seoul 110744, South Korea

来源：

JOURNAL OF MOVEMENT DISORDERS | 2011年 / 4卷 / 02期

关键词：

MicroRNA; Parkinson's disease; Spinocerebellar ataxia; Hereditary spastic paraplegia; Huntington's disease;

D O I：

10.14802/jmd.11011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

MicroRNAs (miRNAs) are small RNAs comprised of 20-25 nucleotides that regulates gene expression by inducing translational repression or degradation of target mRNA. The importance of miRNAs as a mediator of disease pathogenesis and therapeutic targets is rapidly emerging in neuroscience, as well as oncology, immunology, and cardiovascular diseases. In Parkinson's disease and related disorders, multiple studies have identified the implications of specific miRNAs and the polymorphisms of miRNA target genes during the disease pathogenesis. With a focus on Parkinson's disease, spinocerebellar ataxia, hereditary spastic paraplegia, and Huntington's disease, this review summarizes and interprets the observations, and proposes future research topics in this field.

引用

页码：55 / 59

页数：5

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