Adjuvant Use of Ivabradine in Acute Heart Failure due to Myocarditis

被引：13

作者：

Franke, Jennifer ^{[1
]}

Schmahl, Dorothee ^{[1
]}

Lehrke, Stephanie ^{[1
]}

Pribe, Regina ^{[1
]}

Bekeredjian, Raffi ^{[1
]}

Doesch, Andreas O. ^{[1
]}

Ehlermann, Philipp ^{[1
]}

Schnabel, Philipp ^{[2
]}

Katus, Hugo A. ^{[1
]}

Zugck, Christian ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Cardiol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Inst Pathol, D-69120 Heidelberg, Germany

来源：

CASE REPORTS IN MEDICINE | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/203690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report two cases of young men in whom acute heart failure due to myocarditis was diagnosed. The patients had been transferred to the intensive care unit (ICU) with commencing symptoms of acute heart failure and consecutive multiorgan failure for further treatment and to evaluate the indication for implantation of a ventricular assist device or for high urgent orthotopic heart transplantation. In both patients, the I-f-channel inhibitor ivabradine was administered off-label to provide selective heart rate reduction, and thus support hemodynamic stabilization. Though currently considered off-label use in patients suffering from severe hypotension and acute heart failure, the use of ivabradine may beneficially influence outcome by allowing optimization of the patient's heart rate concomitant to initial measures of clinical stabilization.

引用

页数：4

共 8 条

[1] Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure [J].

De Ferrari, Gaetano M. ;

Mazzuero, Antonio ;

Agnesina, Laura ;

Bertoletti, Alessandra ;

Lettino, Maddalena ;

Campana, Carlo ;

Schwartz, Peter J. ;

Tavazzi, Luigi .

EUROPEAN JOURNAL OF HEART FAILURE, 2008, 10 (06) :550-555

[2] Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen [J].

Dedkov, Eduard I. ;

Zheng, Wei ;

Christensen, Lance P. ;

Weiss, Robert M. ;

Mahlberg-Gaudin, Florence ;

Tomanek, Robert J. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (01) :H590-H598

[3] Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial [J].

Fox, Kim ;

Ford, Ian ;

Steg, P. Gabriel ;

Tendera, Michal ;

Ferrari, Roberto .

LANCET, 2008, 372 (9641) :807-816

[4] Effect of ivabradine in dobutamine induced sinus tachycardia in a case of acute heart failure [J].

Link, Andreas ;

Reil, Jan Christian ;

Selejan, Simina ;

Boehm, Michael .

CLINICAL RESEARCH IN CARDIOLOGY, 2009, 98 (08) :513-515

[5] Long-term heart rate reduction induced by the selective If current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure [J].

Mulder, P ;

Barbier, S ;

Chagraoui, A ;

Richard, V ;

Henry, JP ;

Lallemand, F ;

Renet, S ;

Lerebours, G ;

Mahlberg-Gaudin, F ;

Thuillez, C .

CIRCULATION, 2004, 109 (13) :1674-1679

[6] Ivabradine - a New Therapeutic Option for Cardiogenic Shock? [J].

Post, Felix ;

Muenzel, Thomas .

HERZ, 2009, 34 (03) :224-229

[7] Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study [J].

Swedberg, Karl ;

Komajda, Michel ;

Boehm, Michael ;

Borer, Jeffrey S. ;

Ford, Ian ;

Dubost-Brama, Ariane ;

Lerebours, Guy ;

Tavazzi, Luigi .

LANCET, 2010, 376 (9744) :875-885

[8] Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation [J].

Van de Werf, Frans ;

Bax, Jeroen ;

Betriu, Amadeo ;

Blomstrom-Lundqvist, Carina ;

Crea, Filippo ;

Falk, Volkmar ;

Filippatos, Gerasimos ;

Fox, Keith ;

Huber, Kurt ;

Kastrati, Adnan ;

Rosengren, Annika ;

Steg, P. Gabriel ;

Tubaro, Marco ;

Verheugt, Freek ;

Weidinger, Franz ;

Weis, Michael ;

Vahanian, Alec ;

Camm, John ;

De Caterina, Raffaele ;

Dean, Veronica ;

Dickstein, Kenneth ;

Filippatos, Gerasimos ;

Funck-Brentano, Christian ;

Hellemans, Irene ;

Kristensen, Steen Dalby ;

McGregor, Keith ;

Sechtem, Udo ;

Silber, Sigmund ;

Tendera, Michal ;

Widimsky, Petr ;

Zamorano, Jose Luis ;

Silber, Sigmund ;

Aguirre, Frank V. ;

Al-Attar, Nawwar ;

Alegria, Eduardo ;

Andreotti, Felicita ;

Benzer, Werner ;

Breithardt, Ole ;

Danchin, Nicholas ;

Mario, Carlo Di ;

Dudek, Dariusz ;

Gulba, Dietrich ;

Halvorsen, Sigrun ;

Kaufmann, Philipp ;

Kornowski, Ran ;

Lip, Gregory Y. H. ;

Rutten, Frans .

EUROPEAN HEART JOURNAL, 2008, 29 (23) :2909-2945

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