THE EFFICACY OF FLUCONAZOLE IN TREATING PROSTHETIC VALVE ENDOCARDITIS CAUSED BY CANDIDA-GLABRATA - REPORT OF A CASE

被引：7

作者：

NISHIDA, T

MAYUMI, H

KAWACHI, Y

TOKUNAGA, S

MARUYAMA, Y

NAKASHIMA, A

YASUI, H

TOKUNAGA, K

机构：

[1] Division of Cardiovascular Surgery, Research Institute of Angio-cardiology, Faculty of Medicine, Kyushu University, Fukuoka, 812

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1994年 / 24卷 / 07期

关键词：

FUNGAL ENDOCARDITIS; FLUCONAZOLE; PROSTHETIC VALVE ENDOCARDITIS; CARDIAC SURGERY; OPEN HEART SURGERY;

D O I：

10.1007/BF01833735

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A case of active prosthetic valve infective endocarditis (PVE) due to Candida glabrata was successfully treated by the systemic administration of fluconazole. A 66-year-old Japanese man with infective endocarditis of unknown etiology underwent aortic and mitral valve replacement to treat severe aortic and mitral regurgitation associated with multiple organ failure. Postsurgical cultures of arterial blood were repeatedly positive for C. glahrata, and therefore fluconazole was administered either intravenously or orally at a dose of 400 mg/day for 46 days. During that time the signs of inflammation including fever such as an elevated white blood cell count and the presence of C-reactive protein (CRP) all improved while the blood cultures became negative. Fluconazole is thus considered to be effective in treating PVE caused by C. glabrata. When administering this treatment, it is also important to monitor the patient's renal and liver function.

引用

页码：651 / 654

页数：4

共 10 条

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