1H-1,2,4-TRIAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - C-LINKED ANALOGS OF SC-50560

被引：7
|
作者：
REITZ, DB
PENICK, MA
NORTON, MB
REINHARD, EJ
OLINS, GM
CORPUS, VM
PALOMO, MA
MCGRAW, DE
MCMAHON, EG
机构：
[1] Chemistry Searle Research and Development Monsato Company, MO 63198
[2] Cardiovascular Diseases Research Searle Research and Development Monsato Company, MO 63198
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(01)81130-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel 1H-1,2,4-triazole analogs in which the biphenylmethyl group is attached to carbon and the butyl group is attached to the adjacent nitrogen were found to be potent angiotensin II receptor antagonists. Additional substitution at the carbon bearing the biphenyl group proved to be very detrimental to potency. The in vivo properties of the dibutyl analog SC-51757 were found to be similar to SC-50560.
引用
收藏
页码：105 / 110
页数：6
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