ANTIMICROBIAL EFFECTS OF NEWLY SYNTHESIZED ORGANOTIN(IV) AND ORGANOLEAD(IV) DERIVATIVES

Triorganotin(IV) and triorganolead(IV) derivatives of the types Me3Sn(SCZ) and Ph3Pb(SCZ) (where SCZ- is the anion of a semicarbazone ligand) have been synthesized by substitution reactions of trimethyltin chloride and triphenyl-lead chloride with semicarbazones derived from heterocyclic ketones. The resulting complexes have been characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding has been established on the basis of infrared and H-1, C-13 and Sn-119 NMR spectroscopic studies. Some respresentative complexes have also been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria; the results of these investigations have been reported in the present paper.