GENE COMPLEMENTING XERODERMA-PIGMENTOSUM GROUP A CELLS MAPS TO DISTAL HUMAN CHROMOSOME-9Q

被引：13

作者：

HENNING, KA

SCHULTZ, RA

SEKHON, GS

FRIEDBERG, EC

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305

[2] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305

[3] UNIV MARYLAND,DIV HUMAN GENET,BALTIMORE,MD 21201

[4] UNIV WISCONSIN,DIV CLIN GENET,MADISON,WI 53705

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1990年 / 16卷 / 04期

关键词：

D O I：

10.1007/BF01232467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenotypic complementation of xeroderma pigmentosum group A (XP-A) cells by microcell-mediated transfer of a single rearranged neo-tagged human chromosome from a human-mouse somatic cell hybrid designated K3SUB1A9-3 was reported previously. Extended growth of this human-mouse hybrid in culture led to deletion of the small arm of the human chromosome, with concomitant loss of complementing ability when introduced into XP-A cells by microcell-mediated chromosome transfer. Cytogenetic analysis of both hybrids suggests that the complementing locus is on chromosome 9q22.2-q34.3, and Southern blot analysis confirms the presence of distal chromosome 9q sequences. © 1990 Plenum Publishing Corporation.

引用

页码：395 / 400

页数：6

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