Case report: Enteral nutritional supplement as a likely cause of false-positive galactomannan testing

被引:13
作者
Ng, Tong-Yong [1 ]
Kang, Mei-Ling [2 ]
Tani, Ban -Hock [2 ]
Ngan, Cecilia Cheng-Lai [3 ]
机构
[1] Singapore Gen Hosp, Dept Pathol, Singapore, Singapore
[2] Singapore Gen Hosp, Dept Infect Dis, Singapore, Singapore
[3] Chang Gen Hosp, Dept Lab Med, Singapore, Singapore
关键词
Galactomannan; False-positive; Nutritional supplement; Transplant;
D O I
10.1016/j.mmcr.2013.11.004
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The detection of galactomannan (GM) in the serum of in immunocompromised patients is widely used for the early diagnosis of invasive aspergillosis. We report a case of a false-positive GM test presumably caused by the enteral nutritional supplement given to a non-neutropenic patient with intestinal graft versus-host disease after a hematopoietic stem cell transplant. Clinicians should be alert to the possibility of False-positive GM results in patients on nutritional supplements. (C) 2013 The Authors, International Society for Human and Animal Mycology. Published by Elsevier B.V.
引用
收藏
页码:11 / 13
页数:3
相关论文
共 18 条
[1]  
Aceti A, 2008, PEDIATR INFECT DIS J, V27, P769, DOI [10.1097/INF.0b013e31817c0b6e, 10.1097/INF.0b013e31817e840a]
[2]   Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies [J].
Adam, O ;
Aupérin, A ;
Wilquin, F ;
Bourhis, JH ;
Gachot, B ;
Chachaty, E .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (06) :917-920
[3]   Detection of Aspergillus galactomannan antigen in foods and antibiotics [J].
Ansorg, R ;
van den Boom, R ;
Rath, PM .
MYCOSES, 1997, 40 (9-10) :353-357
[4]   Clinical impact of enhanced diagnosis of invasive fungal disease in high-risk haematology and stem cell transplant patients [J].
Barnes, R. A. ;
White, P. L. ;
Bygrave, C. ;
Evans, N. ;
Healy, B. ;
Kell, J. .
JOURNAL OF CLINICAL PATHOLOGY, 2009, 62 (01) :64-69
[5]   Preparation and characterization of molecular weight fractions of guar galactomannans using acid and enzymatic hydrolysis [J].
Cheng, Y ;
Brown, KM ;
Prud'homme, RK .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2002, 31 (1-3) :29-35
[6]   Plasmalyte as a cause of false-positive results for Aspergillus galactomannan in bronchoalveolar lavage fluid [J].
Hage, Chadi A. ;
Reynolds, John M. ;
Durkin, Michelle ;
Wheat, L. Joseph ;
Knox, Kenneth S. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (02) :676-677
[7]   Prognostic Features of Galactomannan Antigenemia in Galactomannan-Positive Invasive Aspergillosis [J].
Koo, Sophia ;
Bryar, Julie M. ;
Baden, Lindsey R. ;
Marty, Francisco M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (04) :1255-1260
[8]   Design issues in studies evaluating diagnostic tests for aspergillosis [J].
Marr, KA ;
Leisenring, W .
CLINICAL INFECTIOUS DISEASES, 2005, 41 :S381-S386
[9]   Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis [J].
Mennink-Kersten, MASH ;
Donnelly, JP ;
Verweij, PE .
LANCET INFECTIOUS DISEASES, 2004, 4 (06) :349-357
[10]   Immune reconstitution inflammatory syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia: Proof of principle, description, and clinical and research implications [J].
Miceli, Marisa H. ;
Maertens, Johan ;
Buve, Kristel ;
Grazziutti, Monica ;
Woods, Gail ;
Rahman, Mazhar ;
Barlogie, Bart ;
Anaissie, Elias J. .
CANCER, 2007, 110 (01) :112-120