HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS AS MARKERS OF EARLY ATHEROSCLEROSIS

被引：33

作者：

ATGER, V ^{[1
]}

GIRAL, P ^{[1
]}

SIMON, A ^{[1
]}

CAMBILLAU, M ^{[1
]}

LEVENSON, J ^{[1
]}

GARIEPY, J ^{[1
]}

MEGNIEN, JL ^{[1
]}

MOATTI, N ^{[1
]}

SEGOND, P ^{[1
]}

BADET, D ^{[1
]}

BAYLACLEBOTT, C ^{[1
]}

DEBONNIERES, A ^{[1
]}

BORIE, A ^{[1
]}

BOURILLON, MF ^{[1
]}

BOURSIER, J ^{[1
]}

BRESSLER, S ^{[1
]}

BRU, M ^{[1
]}

CHENET, M ^{[1
]}

CORTEEL, P ^{[1
]}

COULANGE, C ^{[1
]}

DELMOTTEDEVOCELLE, C ^{[1
]}

DEMURE, B ^{[1
]}

DOUGUET, MT ^{[1
]}

DUBOST, M ^{[1
]}

DRUMARE, T ^{[1
]}

ESTEVE, D ^{[1
]}

FRAGNY, M ^{[1
]}

GALAMAND, O ^{[1
]}

GIARD, AM ^{[1
]}

GITEL, R ^{[1
]}

GUILBERT, C ^{[1
]}

HAGE, H ^{[1
]}

KIESGEN, F ^{[1
]}

LAMOTHE, E ^{[1
]}

LANOISELEE, C ^{[1
]}

LEBLANC, ML ^{[1
]}

LECHEVANTON, N ^{[1
]}

LEPRINCE, I ^{[1
]}

MARTY, A ^{[1
]}

MIARA, D ^{[1
]}

MILLET, B ^{[1
]}

OZIEL, J ^{[1
]}

PARINI, A ^{[1
]}

PASTEAU, MC ^{[1
]}

PICARD, M ^{[1
]}

PUPPONI, MM ^{[1
]}

QUINIO, C ^{[1
]}

RAULET, F ^{[1
]}

ROCCA, ML ^{[1
]}

SZABASON, F ^{[1
]}

机构：

[1] HOP BROUSSAIS,CTR MED PREVENT CARDIOVASC,DEPT BIOCHEM,INSERM,U28,F-75674 PARIS 14,FRANCE

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1995年 / 75卷 / 02期

关键词：

D O I：

10.1016/S0002-9149(00)80060-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although the inverse relation between high-density lipoprotein (HDL) cholesterol concentration and the risk of ischemic heart disease is well established, little is known about the relation of HDL subfractions HDL(2) and HDL(3) or lipoprotein A-I and A-I-A-II to extracoronary disease, particularly at its silent phase before the appearance of clinical lesions. We investigated the potential influence of HDL subfractions as risk markers, among the other main lipid and nonlipid risk factors, early atherosclerotic plaques detected by imaging sites in 181 hypercholesterolemic symptom-free men. No plaques were found in 36% of the patients, but plaques were found at carotid, aortic, and femoral sites in 24%, 40%, and 46% of subjects, respectively. Data were analyzed using univariate comparisons and multiple logistic regression. According to the logistic analysis, plaques were associated (1) with blood pressure (p = 0.008) and low-density lipoprotein (LDL) cholesterol (p = 0.02) in the carotid arteries; (2) with age (p = 0.0005), triglycerides (p = 0.002), and cigarette smoking (p = 0.02) at the aortic site; and (3) inversely with HDL(3) cholesterol (p = 0.0008) and positively with cigarette smoking (p = 0.004), and age (p = 0.04) in the femoral site. The number of arterial sites affected (0, 1, 2, and 3) by plaques was inversely associated with HDL, cholesterol (p = 0.001), and positively associated with smoking = (p = 0.002), blood pressure (p = 0.002), LDL cholesterol (p = 0.003), and age (p = 0.006). Using models of multivariate analysis, we showed that HDL(2) and HDL(3) subfractions were better predictors of plaque at the femoral site and of the number of affected segments than total HDL cholesterol. Thus, in hypercholesterolemic asymptomatic middle-aged men, LDL cholesterol and HDL(3) cholesterol concentrations are 2 specific lipid parameters that strongly influence the development of arterial plaque. A significant increase in the LDL:HDL(3) ratio was associated with the presence of plaque at each site, and also with the number of diseased sites. Our data support the hypothesis of a specific protective effect of HDL, subfraction at the early stage of atherosclerosis, and we propose the LDL:HDL, ratio as a potential marker of the presence and extent of extracoronary plaques.

引用

页码：127 / 131

页数：5

共 31 条

[1] PARTICLE DISTRIBUTION OF HUMAN-SERUM HIGH-DENSITY LIPOPROTEINS [J].

ANDERSON, DW ;

NICHOLS, AV ;

FORTE, TM ;

LINDGREN, FT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 493 (01) :55-68

[2]

ASSMANN C, 1983, CLIN CHEM, V29, P2025

[3]

ATGER V, 1991, CLIN CHEM, V37, P1149

[4] HIGH-DENSITY LIPOPROTEIN SUBFRACTIONS IN NORMOLIPIDEMIC PATIENTS WITH CORONARY ATHEROSCLEROSIS [J].

BROOK, JG ;

AVIRAM, M ;

VIENER, A ;

SHILANSKY, E ;

MARKIEWICZ, W .

CIRCULATION, 1982, 66 (05) :923-926

[5] DECREASED HDL2 AND HDL3 CHOLESTEROL, APO A-I AND APO A-II, AND INCREASED RISK OF MYOCARDIAL-INFARCTION [J].

BURING, JE ;

OCONNOR, GT ;

GOLDHABER, SZ ;

ROSNER, B ;

HERBERT, PN ;

BLUM, CB ;

BRESLOW, JL ;

HENNEKENS, CH .

CIRCULATION, 1992, 85 (01) :22-29

[6]

CHEUNG MC, 1984, J BIOL CHEM, V259, P2201

[7]

CHEUNG MC, 1991, J LIPID RES, V32, P383

[8]

COSTEBUREL M, 1990, CLIN CHEM, V36, P1889

[9] RELATION OF THE LEVEL OF HIGH-DENSITY-LIPOPROTEIN SUBFRACTIONS TO THE PRESENCE AND EXTENT OF CORONARY-ARTERY DISEASE [J].

DREXEL, H ;

AMANN, FW ;

RENTSCH, K ;

NEUENSCHWANDER, C ;

LUETHY, A ;

KHAN, SI ;

FOLLATH, F .

AMERICAN JOURNAL OF CARDIOLOGY, 1992, 70 (04) :436-440

[10]

EISENBERG S, 1984, J LIPID RES, V25, P1017

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