INHIBITING EFFECTS OF SEROTONIN ANTAGONISTS ON THE PROLIFERATION OF MERCURIC-CHLORIDE STIMULATED HUMAN PERIPHERAL-BLOOD LYMPHOCYTES-T

被引：23
作者：
NORDLIND, K
SUNDSTROM, E
BONDESSON, L
机构：
[1] HUDDINGE HOSP,DEPT GERIATR MED,STOCKHOLM,SWEDEN
[2] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 97卷 / 02期
关键词：
SEROTONIN; KETANSERIN; METHIOTEPINE; MERCURIC CHLORIDE; LYMPHOCYTES;
D O I：
10.1159/000236104
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
The serotonin antagonists ketanserin and methiotepine were tested for a modulating effect on the proliferative response of human peripheral blood T lymphocytes to mercuric chloride. This response was inhibited by ketanserin at 8 X 10(-5) mol/l and by methiotepine at 8.0 x 10(-6) mol/l. There were no additive effects at these concentrations of antagonists and at 10(-5) mol/l of serotonin. Low concentrations of ketanserin eliminated the inhibiting effect of serotonin on mercuric chloride induced proliferation of T lymphocytes. It thus seems as if the inhibiting effect of serotonin on T lymphocytes is mediated by 5-HT1c, or 5-HT2 receptors, while the mechanism for the intrinsic inhibiting effect of the antagonists at present is unknown.
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页码：105 / 108
页数：4
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