EXPERIMENTAL PHARMACOKINETICS OF BIOLOGICALLY-ACTIVE PLANT PHENOLIC-COMPOUNDS .2. PHARMACOKINETICS OF LIKVIRITIN IN THE RAT

被引：1

作者：

VOSKOBOINIKOVA, IV ^{[1
]}

TJUKAVKINA, NA ^{[1
]}

KOLHIR, VK ^{[1
]}

GEODAKYAN, SV ^{[1
]}

ZJUZIN, VA ^{[1
]}

KOLESNIK, YA ^{[1
]}

LITVINENKO, VI ^{[1
]}

机构：

[1] MOSCOW MED ACAD,DEPT ORGAN CHEM,5TH PARKOVAJA ST 21,MOSCOW 105043,RUSSIA

来源：

PHYTOTHERAPY RESEARCH | 1993年 / 7卷 / 01期

关键词：

LIKVIRITIN; 2,3-DIHYDRO-2(4'-GLUKOSILOXYPHENIL)-7-HYDROXY-4-H-1-BENZOPIRANON-4; GLYCYRRHIZA-GLABRA; PHARMACOKINETICS IN RATS;

D O I：

10.1002/ptr.2650070120

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A procedure was developed to measure plasma and urine likviritin levels by reversed-phase high performance liquid chromatography. The likviritin pharmacokinetics was studied in rats after intravenous injection of the compound in a single dose of 1, 3 and 10 mg/kg and after its oral administration in a single dose 50 and 500 mg/kg. It was shown that likviritin pharmacokinetics after i.v. injection within the above dose range was nonlinear and within every dose could be described by a two-compartmental model. Its nonlinear nature might be associated with saturated binding of the compound.

引用

页码：84 / 86

页数：3

共 2 条

[1] EXPERIMENTAL PHARMACOKINETICS OF BIOLOGICALLY-ACTIVE PLANT PHENOLIC-COMPOUNDS .1. PHARMACOKINETICS OF MANGIFERIN IN THE RAT
GEODAKYAN, SV
VOSKOBOINIKOVA, IV
TJUKAVKINA, NA
KOLHIR, VK
KOLESNIK, YA
ZJUZIN, VA
GLYZIN, VI
SOKOLOV, SJ
PHYTOTHERAPY RESEARCH, 1992, 6 (06) : 332 - 334
[2] EXPERIMENTAL PHARMACOKINETICS OF BIOLOGICALLY-ACTIVE PLANT PHENOLIC-COMPOUNDS .3. PHARMACOKINETICS OF DIHYDROQUERCETIN
VOSKOBOINIKOVA, IV
TJUKAVKINA, NA
GEODAKYAN, SV
KOLESNIK, YA
KOLHIR, VK
ZJUZIN, VA
SOKOLOV, SJ
PHYTOTHERAPY RESEARCH, 1993, 7 (02) : 208 - 210

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