THE HUMAN PYRUVATE-DEHYDROGENASE COMPLEX - A POLYMORPHIC REGION OF THE LIPOATE ACETYL TRANSFERASE (E2) SUBUNIT GENE

被引：4
作者：
MOEHARIO, LH
WANG, L
DEVENISH, RJ
MACKAY, IR
MARZUKI, S
机构：
[1] MONASH UNIV,DEPT BIOCHEM,CLAYTON,VIC 3168,AUSTRALIA
[2] MONASH UNIV,CTR MOLEC BIOL & MED,CLAYTON,VIC 3168,AUSTRALIA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1097卷 / 02期
基金：
英国医学研究理事会;
关键词：
PYRUVATE DEHYDROGENASE COMPLEX; BILIARY CIRRHOSIS; POLYMORPHISM; CDNA;
D O I：
10.1016/0925-4439(91)90096-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A major issue in the study of the pathogenesis of primary biliary cirrhosis is whether the E2 subunit of the pyruvate dehydrogenase complex (PDH-E2), the major autoantigen in the disease, exists as a tissue-specific isoform. cDNA clones spanning a segment of the 3'-catalytic region of PDH-E2 (nt 1158-1361) have been isolated from human kidney, placenta and bile epithelium cells. Nucleotide sequence analysis of the clones showed differences consistent with the presence of normal variants of PDH-E2 in the human population. However, the existence of tissue-specific isoforms of PDH-E2 cannot yet be discounted.
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收藏
页码：128 / 132
页数：5
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