AGE-RELATED-CHANGES IN GLUTATHIONE SYNTHESIS IN THE EYE LENS

被引：28

作者：

FERRER, JV ^{[1
]}

GASCO, E ^{[1
]}

SASTRE, J ^{[1
]}

PALLARDO, FV ^{[1
]}

ASENSI, M ^{[1
]}

VINA, J ^{[1
]}

机构：

[1] FAC MED VALENCIA, DEPT FISIOL, AVDA BLASCO IBANEZ 17, E-46010 VALENCIA, SPAIN

来源：

BIOCHEMICAL JOURNAL | 1990年 / 269卷 / 02期

关键词：

D O I：

10.1042/bj2690531

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eye lenses from young rats or mice synthesize GSH from methionine or N-acetylcysteine. However, lenses from old animals do not synthesize GSH from methionine. This is due to the absence of cystathionase activity in old lenses. GSH monoethyl ester, but not free GSH, increases GSH content and protects the lens against experimental oxidative stress. The importance of these results in the prevention of cataractogenesis is discussed.

引用

页码：531 / 534

页数：4

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