PATHOGENICITY OF ACANTHAMOEBA AND A CORYNEBACTERIUM IN THE RAT CORNEA

被引：49
作者：
BADENOCH, PR
JOHNSON, AM
CHRISTY, PE
COSTER, DJ
机构：
[1] STATE WATER LAB,BOLIVAR,SA,AUSTRALIA
[2] FLINDERS UNIV,MED CTR,DEPT CLIN MICROBIOL,BEDFORD PK,SA 5042,AUSTRALIA
来源：
ARCHIVES OF OPHTHALMOLOGY | 1990年 / 108卷 / 01期
关键词：
D O I：
10.1001/archopht.1990.01070030113040
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Acanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition. © 1990, American Medical Association. All rights reserved.
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页码：107 / 112
页数：6
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