Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review

被引：0

作者：

Karapinar, Tuba Hilkay ^{[1
]}

Oymak, Yesim ^{[1
]}

Ecevit, Cigdem ^{[2
]}

Yilmaz, Funda ^{[3
]}

Karakoyun, Miray ^{[4
]}

Ay, Yilmaz ^{[1
]}

Vergin, Canan ^{[1
]}

机构：

[1] Cocuk Hastaliklari Cerrahisi Egitim Arastirma Has, Cocuk Hematol Onkol Klin, Izmir, Turkey

[2] Cocuk Hastaliklari Cerrahisi Egitim Arastirma Has, Cocuk Gastroenterol Onkol Klin, Izmir, Turkey

[3] Ege Univ, Tip Fak, Patol Anabilim Dali, Izmir, Turkey

[4] Ege Univ Tip Fak, Cocuk Sagligi Hastaliklari Anabilim Dali, Cocuk Gastroenterol Hepatol Beslenme Bilim, Izmir, Turkey

来源：

JOURNAL OF PEDIATRIC RESEARCH | 2015年 / 2卷 / 02期

关键词：

6-Thioguanine; hepatotoxicity; leukemia;

D O I：

10.4274/jpr.69885

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.

引用

页码：102 / 104

页数：3

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[21] Chronic myeloid leukemia in hemophilia B.: Report of one case [J].

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