Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review

被引：0
|
作者：
Karapinar, Tuba Hilkay [1 ]
Oymak, Yesim [1 ]
Ecevit, Cigdem [2 ]
Yilmaz, Funda [3 ]
Karakoyun, Miray [4 ]
Ay, Yilmaz [1 ]
Vergin, Canan [1 ]
机构：
[1] Cocuk Hastaliklari Cerrahisi Egitim Arastirma Has, Cocuk Hematol Onkol Klin, Izmir, Turkey
[2] Cocuk Hastaliklari Cerrahisi Egitim Arastirma Has, Cocuk Gastroenterol Onkol Klin, Izmir, Turkey
[3] Ege Univ, Tip Fak, Patol Anabilim Dali, Izmir, Turkey
[4] Ege Univ Tip Fak, Cocuk Sagligi Hastaliklari Anabilim Dali, Cocuk Gastroenterol Hepatol Beslenme Bilim, Izmir, Turkey
来源：
JOURNAL OF PEDIATRIC RESEARCH | 2015年 / 2卷 / 02期
关键词：
6-Thioguanine; hepatotoxicity; leukemia;
D O I：
10.4274/jpr.69885
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.
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收藏
页码：102 / 104
页数：3
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