Undergraduate college students are a completely unique at hazard population for the development of suicidal ideation and depression. Researchers have indicated an overall increase in risk factors related to depression and suicidal ideation amongst the college students including anxiety, eating disorders, substance abuse, fear, alcohol abuse, anger, and hostility. The present review plans to get an all-encompassing picture of personality with loneliness pattern and depression status of two different communities in Sikkim. 70 undergraduate college female students aged between 19 to 24 years from two distinct groups (35 Nepali and 35 Lepcha students) studying in 4 different colleges of Sikkim was chosen for information gathering. Varied scales like Eysenck Personality Questionnaire-Revised, Beck Depression Inventory-II, and UCLA Loneliness Scale were chosen for the collecting of information. The results demonstrated that there exists a significant and positive relationship between psychoticism, neuroticism, overall personality, loneliness and depression among Nepali and Lepcha community of Sikkim. Mean scores on loneliness, depression, psychoticism, extraversion, and neuroticism propose that undergraduate college female students from Nepali communities have scored high contrasted with female students from Lepcha community. There also exists a significant difference between undergraduate college female students from Nepali and Lepcha communities on overall personality, and in addition on psychoticism. The conclusion recommend that undergraduate female students from Lepcha community of Sikkim are showing low scores on loneliness, depression, neuroticism and psychoticism in comparison to Nepali community which could be because of the tremendously cohesive group.