THE INFLUENCE OF BRAIN ACETALDEHYDE ON OXIDATIVE STATUS, DOPAMINE METABOLISM AND VISUAL-DISCRIMINATION TASK

被引：56
|
作者：
HEAP, L
WARD, RJ
ABIAKA, C
DEXTER, D
LAWLOR, M
PRATT, O
THOMSON, A
SHAW, K
PETERS, TJ
机构：
[1] UNIV LONDON KINGS COLL,SCH MED & DENT,DEPT CLIN BIOCHEM,LONDON SE5 9PJ,ENGLAND
[2] UNIV LONDON KINGS COLL,PHARM GRP,NEURODEGENERAT DIS RES GRP,LONDON SE5 9PJ,ENGLAND
[3] BEXLEY HOSP,ELMDENE UNIT,KENT,ENGLAND
来源：
BIOCHEMICAL PHARMACOLOGY | 1995年 / 50卷 / 02期
关键词：
ACETALDEHYDE; OXIDATIVE STRESS; DOPAMINE METABOLISM; LIVER; BRAIN;
D O I：
10.1016/0006-2952(94)00539-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The toxic effect of acetaldehyde on brain oxidative capacity and dopamine metabolism has been investigated in rat brains after a single intraperitoneal injection of acetaldehyde (5 mmol/kg) and the results compared with those from chronically ethanol fed rats. Acetaldehyde was present in rat brain 120 hr after a single dose of acetaldehyde, confirming that it is able to cross the blood-brain barrier. Brain catalase increased significantly after acetaldehyde or chronic ethanol administration although there were no other significant changes in the total brain activity of superoxide dismutase, glutathione peroxidase or glutathione reductase. Dopamine turnover was increased in both experimental groups. The acute dose of acetaldehyde reduced the ability of the rats to relearn a computer visual discrimination task.
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页码：263 / 270
页数：8
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