ANTIVIRAL ACTIVITY OF NERVE GROWTH-FACTOR IN-VITRO

被引：0

作者：

UNGHERI, D ^{[1
]}

VERINI, MA ^{[1
]}

GANCEFF, L ^{[1
]}

MAZUE, G ^{[1
]}

CARMINATI, P ^{[1
]}

机构：

[1] FARMITALIA CARLO ERBA SPA,DEPT RES & DEV,I-20014 NERVIANO,ITALY

来源：

DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH | 1993年 / 19卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antiviral activity of 'nerve growth factor' (NGF) on non-oncogenic DNA, on RNA viruses and on Moloney sarcoma retrovirus was evaluated in vitro. NGF was active against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and Moloney sarcoma virus (MSV) at non toxic concentrations. The effects of different treatment regimens on HSV-1 infections indicate that the inhibitory action of NGF occurs at the early stages of viral replication. No activity was noted against coxsackie virus B1 (Cox B1), respiratory syncytial virus (RSV), Semliki forest virus (SFV), encephalomyocarditis (Columbia SK) and adenovirus of infectious canine hepatitis (ICH) at the highest concentrations tested.

引用

页码：151 / 157

页数：7

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