ANTIVIRAL ACTIVITY OF NERVE GROWTH-FACTOR IN-VITRO

被引：0

作者：

UNGHERI, D ^{[1
]}

VERINI, MA ^{[1
]}

GANCEFF, L ^{[1
]}

MAZUE, G ^{[1
]}

CARMINATI, P ^{[1
]}

机构：

[1] FARMITALIA CARLO ERBA SPA,DEPT RES & DEV,I-20014 NERVIANO,ITALY

来源：

DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH | 1993年 / 19卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antiviral activity of 'nerve growth factor' (NGF) on non-oncogenic DNA, on RNA viruses and on Moloney sarcoma retrovirus was evaluated in vitro. NGF was active against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and Moloney sarcoma virus (MSV) at non toxic concentrations. The effects of different treatment regimens on HSV-1 infections indicate that the inhibitory action of NGF occurs at the early stages of viral replication. No activity was noted against coxsackie virus B1 (Cox B1), respiratory syncytial virus (RSV), Semliki forest virus (SFV), encephalomyocarditis (Columbia SK) and adenovirus of infectious canine hepatitis (ICH) at the highest concentrations tested.

引用

页码：151 / 157

页数：7

共 19 条

[1] NERVE GROWTH FACTOR FROM MOUSE SUBMAXILLARY GLAND - AMINO ACID SEQUENCE [J].

ANGELETT.RH ;

BRADSHAW, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (10) :2417-&

[2] NERVE GROWTH FACTOR FROM COBRA VENOM [J].

ANGELETTI, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 65 (03) :668-+

[3] INSITU DETECTION OF MYCOPLASMA CONTAMINATION IN CELL-CULTURES BY FLUORESCENT HOECHST-33258 STAIN [J].

CHEN, TR .

EXPERIMENTAL CELL RESEARCH, 1977, 104 (02) :255-262

[4] ISOLATION AND BIOCHEMICAL-CHARACTERIZATION OF THE MAMMALIAN REOVIRUS TYPE-3 CELL-SURFACE RECEPTOR [J].

CO, MS ;

GAULTON, GN ;

FIELDS, BN ;

GREENE, MI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (05) :1494-1498

[5]

DUNNETT CW, 1964, BIOMETRICS, V20, P483

[6] EPIDERMAL GROWTH-FACTOR RECEPTOR OCCUPANCY INHIBITS VACCINIA VIRUS-INFECTION [J].

EPPSTEIN, DA ;

MARSH, YV ;

SCHREIBER, AB ;

NEWMAN, SR ;

TODARO, GJ ;

NESTOR, JJ .

NATURE, 1985, 318 (6047) :663-665

[7] MORPHOLOGICAL RESPONSE OF AXOTOMIZED SEPTAL NEURONS TO NERVE GROWTH-FACTOR [J].

GAGE, FH ;

ARMSTRONG, DM ;

WILLIAMS, LR ;

VARON, S .

JOURNAL OF COMPARATIVE NEUROLOGY, 1988, 269 (01) :147-155

[8] NERVE GROWTH-FACTOR - BIOCHEMISTRY, SYNTHESIS, AND MECHANISM OF ACTION [J].

GREENE, LA ;

SHOOTER, EM .

ANNUAL REVIEW OF NEUROSCIENCE, 1980, 3 :353-402

[9] FIBROBLAST GROWTH-FACTOR RECEPTOR IS A PORTAL OF CELLULAR ENTRY FOR HERPES-SIMPLEX VIRUS TYPE-1 [J].

KANER, RJ ;

BAIRD, A ;

MANSUKHANI, A ;

BASILICO, C ;

SUMMERS, BD ;

FLORKIEWICZ, RZ ;

HAJJAR, DP .

SCIENCE, 1990, 248 (4961) :1410-1413

[10] DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN [J].

LEVIMONTALCINI, R ;

BOOKER, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1960, 46 (03) :384-391

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