CALCIUM-BINDING PROTEINS - DIFFERENTIAL REGULATION IN INTESTINE, KIDNEY, AND BRAIN

Distinct tissue specificity has been observed regarding regulation of calcium-binding protein expression. Intestinal calcium-binding protein expression is dependent on 1,25-dihydroxyvitamin D. In the vitamin D-replete chick, serum calcium and phosphorus may exert posttranscriptional effects on calcium-binding protein synthesis. Renal calcium-binding protein is constitutively expressed but can be modulated by 1,25-dihydroxyvitamin D administration. In contrast, brain calcium-binding protein expression is independent of vitamin D status.