Use of Telomere Length as a Biomarker for Aging and Age-Related Disease

被引：0

作者：

Fossel, Michael

机构：

来源：

CURRENT GERIATRICS REPORTS | 2012年 / 1卷 / 02期

关键词：

Telomeres; Aging; Telomerase; Age-related disease; Biomarkers;

D O I：

10.1007/s13670-012-0013-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Telomeres (measured as leukocyte telomere length) can be effective and useful biomarkers for general aging status, for age-related disease diagnosis, and for disease status, but they are less effective as predictive biomarkers for patient mortality. Recent work also suggests that we may be able to intervene in this biomarker by re-lengthening telomeres, and that this intervention may have significant clinical benefits. A great deal remains unknown regarding the limits of telomere lengths as clinical biomarkers and the limits of interventions aimed at re-lengthening human telomeres.

引用

页码：121 / 127

页数：7

共 47 条

[31] Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty [J].

Ozsarlak-Sozer, Gonen ;

Kerry, Zeliha ;

Gokce, Goksel ;

Oran, Ismail ;

Topcu, Zeki .

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2011, 67 (01) :35-42

[32] Telomere Length in Prospective and Retrospective Cancer Case-Control Studies [J].

Pooley, Karen A. ;

Sandhu, Manjinder S. ;

Tyrer, Jonathan ;

Shah, Mitul ;

Driver, Kristy E. ;

Luben, Robert N. ;

Bingham, Sheila A. ;

Ponder, Bruce A. J. ;

Pharoah, Paul D. P. ;

Khaw, Kay-Tee ;

Easton, Douglas F. ;

Dunning, Alison M. .

CANCER RESEARCH, 2010, 70 (08) :3170-3176

[33] Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers [J].

Rampazzo, E. ;

Bertorelle, R. ;

Serra, L. ;

Terrin, L. ;

Candiotto, C. ;

Pucciarelli, S. ;

Del Bianco, P. ;

Nitti, D. ;

De Rossi, A. .

BRITISH JOURNAL OF CANCER, 2010, 102 (08) :1300-1305

[34] Ulcerative Colitis-Associated Colorectal Cancer Arises in a Field of Short Telomeres, Senescence, and Inflammation [J].

Risques, Rosa Ana ;

Lai, Lisa A. ;

Himmetoglu, Cigdem ;

Ebaee, Anoosheh ;

Li, Lin ;

Feng, Ziding ;

Bronner, Mary P. ;

Al-Lahham, Bassel ;

Kowdley, Kris V. ;

Lindor, Keith D. ;

Rabinovitch, Peter S. ;

Brentnall, Teresa A. .

CANCER RESEARCH, 2011, 71 (05) :1669-1679

[35]

Sanders J, 2011, J GERONTOL A

[36] The Association of Cataract With Leukocyte Telomere Length in Older Adults: Defining a New Marker of Aging [J].

Sanders, Jason L. ;

Iannaccone, Alessandro ;

Boudreau, Robert M. ;

Conley, Yvette P. ;

Opresko, Patricia L. ;

Hsueh, Wen-Chi ;

Cummings, Steven R. ;

Cawthon, Richard M. ;

Harris, Tamara B. ;

Nalls, Michael A. ;

Kritchevsky, Steven B. ;

Newman, Anne B. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2011, 66 (06) :639-645

[37] Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease [J].

Savale, Laurent ;

Chaouat, Ari ;

Bastuji-Garin, Sylvie ;

Marcos, Elisabeth ;

Boyer, Laurent ;

Maitre, Bernard ;

Sarni, Mourad ;

Housset, Bruno ;

Weitzenblum, Emmanuel ;

Matrat, Mireille ;

Le Corvoisier, Philippe ;

Rideau, Dominique ;

Boczkowski, Jorge ;

Dubois-Rande, Jean-Luc ;

Chouaid, Christos ;

Adnot, Serge .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (07) :566-571

[38] Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia [J].

Scheinberg, Phillip ;

Cooper, James N. ;

Sloand, Elaine M. ;

Wu, Colin O. ;

Calado, Rodrigo T. ;

Young, Neal S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2010, 304 (12) :1358-1364

[39] Telomeres and cardiovascular disease -: Does size matter? [J].

Serrano, AL ;

Andrés, V .

CIRCULATION RESEARCH, 2004, 94 (05) :575-584

[40] Association of Telomere Length in Older Men With Mortality and Midlife Body Mass Index and Smoking [J].

Strandberg, Timo E. ;

Saijonmaa, Outi ;

Tilvis, Reijo S. ;

Pitkala, Kaisu H. ;

Strandberg, Arto Y. ;

Miettinen, Tatu A. ;

Fyhrquist, Frej .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2011, 66 (07) :815-820

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