The Many Faces of Interleukin-6: The Role of IL-6 in Inflammation, Vasculopathy, and Fibrosis in Systemic Sclerosis

被引：95

作者：

Barnes, Theresa C.

Anderson, Marina E.

Moots, Robert J. ^{[1
]}

机构：

[1] Univ Liverpool, Inst Chron Dis & Ageing, Dept Rheumatol, Longmoor Lane, Liverpool L9 7AL, Merseyside, England

来源：

INTERNATIONAL JOURNAL OF RHEUMATOLOGY | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/721608

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-6 is currently attracting significant interest as a potential therapeutic target in systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the evidence for interleukin-6 dysregulation in SSc is explored. The role of inteleukin-6 classical and trans signalling pathways in SSc relevant phenomena such as chronic inflammation, autoimmunity, endothelial cell dysfunction, and fibrogenesis is discussed. The existing evidence that interventions designed to block interleukin-6 signalling are of therapeutic relevance in SSc is evaluated.

引用

页数：6

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