CYP2D6-DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM IN MULTIPLE SYSTEM ATROPHY

被引：14

作者：

PLANTEBORDENEUVE, V

BANDMANN, O

WENNING, G

QUINN, NP

DANIEL, SE

HARDING, AE

机构：

[1] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,NEUROGENET SECT,LONDON WC1N 3BG,ENGLAND

[2] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,MOVEMENT DISORDERS SECT,LONDON WC1N 3BG,ENGLAND

[3] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,PARKINSONS DIS SOC BRAIN BANK,LONDON WC1N 3BG,ENGLAND

来源：

MOVEMENT DISORDERS | 1995年 / 10卷 / 03期

关键词：

MULTIPLE SYSTEM ATROPHY; CYTOCHROME P450; PARKINSONS DISEASE;

D O I：

10.1002/mds.870100307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant yaffles in large series of patients with Parkinson's disease (PD) when compared with controls. We have investigated CYP2D6 polymorphism in 91 patients with multiple system atrophy (MSA) in order to determine if this finding is specific to PD or if there is similar evidence of genetic susceptibility to neurotoxicity in MSA. The distribution of CYP2D6 alleles was not significantly different between MSA patients and controls, and there were fewer poor metabolisers in the MSA group than in the control group.

引用

页码：277 / 278

页数：2

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