COUP-TF - AN ORPHAN MEMBER OF THE STEROID/THYROID HORMONE-RECEPTOR SUPERFAMILY

被引：51
|
作者：
QIU, YH
TSAI, SY
TSAI, MJ
机构：
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 06期
关键词：
D O I：
10.1016/1043-2760(94)P3081-H
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
COUP-TFs ave orphan members of the steroid/thyroid hormone receptor superfamily. They ave transcription factors that are highly conserved across species and have a wide spectrum of binding specificity. In tissue cultures, COUP-TFs repress the transactivation function of several other members of the steroid/thyroid hormone receptor superfamily, and they also negatively regulate the transcription from promoters of many other genes. The expression profile of COUP-TFs in several species suggests that they play an important role in development and differentiation.
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页码：234 / 239
页数：6
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