APPLICATION OF ORGANOLITHIUM AND RELATED REAGENTS IN SYNTHESIS .15. A CONCISE REGIOSPECIFIC CONVERSION OF PICOLINIC ACIDS AND ISONICOTINIC ACIDS INTO 2-BENZOYLNICOTINIC AND 4-BENZOYLNICOTINIC ACIDS

被引：21

作者：

EPSZTAJN, J

JOZWIAK, A

SZCZESNIAK, AK

机构：

[1] Department of Organic Chemistry, University of Ló dź, 90-136 Ló dź

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 13期

关键词：

D O I：

10.1080/00397919408010186

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the azaphthalides (7) and (8) and their conversion into the corresponding 2- and 4-benzoyl-3-hydroxymethylpyridines (9) and (10), very useful precursors of the 2- and 4-benzoylated nicotinic acids (11) and (12), as a way of regiospecific transformation of the picolin- and isonicotinanilides (1) and (2) into nicotinic acid derivatives, is described.

引用

页码：1789 / 1798

页数：10

共 18 条

[1] SYNTHESIS OF 2,10-DIPHENYL-2H-PYRIDAZINO[4,5-B]QUINOLIN-1-ONE AND 2,3-DIHYDRO-9-PHENYL-2-PHENYLAMINO-1H-PYRROLO[3,4-B]QUINOLIN-1-ONE DERIVATIVES AS PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR LIGANDS [J].