DYNAMIC BALANCE CHANGES BETWEEN ELASTASE AND ANTIPROTEASE IN THE EARLY STAGES AFTER SMOKE-INHALATION INJURY

被引：2

作者：

XIE, EF

LI, AN

YANG, ZC

JIANG, KY

机构：

[1] Institute of Bum Research, Southwestern Hospital, Third Military Medical College, Chongqing

来源：

BURNS | 1992年 / 18卷 / 05期

关键词：

D O I：

10.1016/0305-4179(92)90033-Q

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Following the use of a rabbit smoke inhalation injury model established in this institute, there were marked reductions in elastase activities in neutrophils and alveolar macrophages, rapid increases in elastase activity in broncho-alveolar lavage fluid (BALF), reductions of serum trypsin inhibitory capacity; a decrease of PaO2 and an increase of PaCO2, and marked increases of lung water volume. Significant correlations were found between the increased extravascular lung water content and the rising elastase activity in BALF. It seems probable that the imbalance between elastase and antiprotease played an important role in the development of acute lung injury after smoke inhalation.

引用

页码：362 / 367

页数：6

共 17 条

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