EFFECT OF ENDOTHELIN ON ANGIOTENSIN CONVERTING ENZYME-ACTIVITY IN CULTURED PULMONARY-ARTERY ENDOTHELIAL-CELLS

被引：52
作者：
KAWAGUCHI, H
SAWA, H
YASUDA, H
机构：
[1] Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo
来源：
JOURNAL OF HYPERTENSION | 1991年 / 9卷 / 02期
关键词：
ENDOTHELIN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN-I; ANGIOTENSIN-II; PULMONARY ENDOTHELIAL CELL;
D O I：
10.1097/00004872-199102000-00012
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
We studied the effects of endothelin on angiotensin converting enzyme (ACE) in cultured pulmonary artery endothelial cells. ACE activity was increased 2.5-fold by the addition of 1 x 10(-8) mol/l endothelin-1. Endothelin-1 also stimulated calcium influx and phospholipase C activity in a dose-dependent manner. Calcium influx, phospholipase C and ACE activity were suppressed 60-70% in the presence of endothelin-1 (10(-10) to 10(-6) mol/l) by 50-mu-l neomycin. These results suggest that ACE was stimulated by endothelin-1 and that its activity may be closely related to phosphatidylinositol turnover stimulated by endothelin-1.
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收藏
页码：171 / 174
页数：4
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