INTRACELLULAR DISTRIBUTION OF SUBMAXILLARY KALLIKREIN

被引：26

作者：

BHOOLA, KD

机构：

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 1968年 / 196卷 / 02期

关键词：

D O I：

10.1113/jphysiol.1968.sp008516

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1. Differential centrifugation and sucrose density‐gradient data indicate that kallikrein in the submaxillary gland is associated with particles which sediment with the nuclear and heavy mitochondrial fractions and equilibrate with 1·7‐1·8 M sucrose. 2. The sedimentation properties of the kallikrein containing particles differ from those of mitochondria and lysosomes, but resemble those of the pancreatic zymogen granules. 3. Histological observations indicate that kallikrein is associated with basophilic particles which stain positively with Periodic Acid‐Schiff reagent. 4. Pilocarpine causes a preferential secretion of kallikrein and amylase into saliva. 5. The results would support an exocrine role for submaxillary kallikrein. © 1968 The Physiological Society

引用

页码：431 / +

页数：1

共 15 条

[1] TISSUE FRACTIONATION STUDIES .18. RESOLUTION OF MITOCHONDRIAL FRACTIONS FROM RAT LIVER INTO 3 DISTINCT POPULATIONS OF CYTOPLASMIC PARTICLES BY MEANS OF DENSITY EQUILIBRATION IN VARIOUS GRADIENTS [J].