NUCLEIC-ACID RELATED-COMPOUNDS .40. SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 5-ALKYNYLURACIL NUCLEOSIDES

被引:110
作者
DECLERCQ, E [1 ]
DESCAMPS, J [1 ]
BALZARINI, J [1 ]
GIZIEWICZ, J [1 ]
BARR, PJ [1 ]
ROBINS, MJ [1 ]
机构
[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA
关键词
D O I
10.1021/jm00359a008
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:661 / 666
页数:6
相关论文
共 32 条
[1]   ON THE MECHANISM OF SELECTIVE-INHIBITION OF HERPESVIRUS REPLICATION BY (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE [J].
ALLAUDEEN, HS ;
KOZARICH, JW ;
BERTINO, JR ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :2698-2702
[2]   ROLE OF THYMIDINE KINASE IN THE INHIBITORY ACTIVITY OF 5-SUBSTITUTED-2'-DEOXYURIDINES ON THE GROWTH OF HUMAN AND MURINE TUMOR-CELL LINES [J].
BALZARINI, J ;
DECLERCQ, E ;
TORRENCE, PF ;
MERTES, MP ;
PARK, JS ;
SCHMIDT, CL ;
SHUGAR, D ;
BARR, PJ ;
JONES, AS ;
VERHELST, G ;
WALKER, RT .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (06) :1089-1095
[3]   INHIBITION OF THYMIDYLATE SYNTHETASE BY 5-ALKYNYL-2'-DEOXYURIDYLATES [J].
BARR, PJ ;
NOLAN, PA ;
SANTI, DV ;
ROBINS, MJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (12) :1385-1388
[4]   SYNTHESIS OF NUCLEOSIDES DERIVED FROM 5-ETHYNYLURACIL AND 5-ETHYNYL-CYTOSINE [J].
BARR, PJ ;
JONES, AS ;
SERAFINOWSKI, P ;
WALKER, RT .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1978, (10) :1263-1267
[5]  
BOBEK M, 1978, CHEM BIOL NUCLEOSIDE, P135
[6]   INORGANIC LINKAGE ISOMERISM OF THIOCYANATE ION [J].
BURMEISTER, JL ;
BASOLO, F .
INORGANIC CHEMISTRY, 1964, 3 (11) :1587-&
[7]  
Busson R., 1981, NUCLEIC ACIDS RES S, V9, P49
[8]  
CHENG YC, 1981, MOL PHARMACOL, V20, P230
[9]   ANTIVIRAL ACTIVITY OF 5-ETHYL PYRIMIDINE DEOXYNUCLEOSIDES [J].
DECLERCQ, E ;
SHUGAR, D .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (10) :1073-1078
[10]   ANTI-VIRAL, ANTI-TUMOR, AND THYMIDYLATE SYNTHETASE INHIBITION STUDIES OF 5-SUBSTITUTED STYRYL DERIVATIVES OF 2'-DEOXYURIDINE AND THEIR 5'-PHOSPHATES [J].
DECLERCQ, E ;
BALZARINI, J ;
DESCAMPS, J ;
BIGGE, CF ;
CHANG, CTC ;
KALARITIS, P ;
MERTES, MP .
BIOCHEMICAL PHARMACOLOGY, 1981, 30 (05) :495-502