REGIONAL LOCALIZATION OF THE HUMAN INTEGRIN BETA(6) GENE (ITGB6) TO CHROMOSOME 2Q24-Q31

被引：12
|
作者：
FERNANDEZRUIZ, E [1 ]
SANCHEZMADRID, F [1 ]
机构：
[1] UNIV AUTONOMA MADRID,HOSP PRINCESA,DEPT INMUNOL,E-28006 MADRID,SPAIN
来源：
GENOMICS | 1994年 / 21卷 / 03期
关键词：
D O I：
10.1006/geno.1994.1325
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The heterodimer alpha(v) beta(6) acts as a fibronectin receptor for human carcinoma cells. We report here the regional localization of the beta(6) gene to 2q24-q31 by fluorescence in situ hybridization coupled with GTG-banding. This gene is located close to the region to which genes coding for the cu subunits of the integrins VLA-4 and vitronectin receptor (ITGA4 and ITGAV, respectively) have been previously mapped (2q31-q32). These data suggest a proximal position of the integrin beta(6) locus (ITGB6) on this integrin gene cluster. Furthermore, double-labeling in situ hybridization experiments performed with alpha(4) and alpha(v) probes indicated a telomeric position of ITGAV with respect to ITGA4. (C) 1994 Academic Press, Inc.
引用
收藏
页码：638 / 640
页数：3
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