Immunohistochemistry for an improved clinical workflow in the era of personalized melanoma therapy?

被引:0
作者
Massi, Daniela [1 ]
Mandala, Mario [2 ]
机构
[1] Univ Florence, Div Anat Pathol, Dept Surg Translat Med, Florence, Italy
[2] Papa Giovanni XXIII Hosp, Dept Hematol Oncol, Med Oncol Unit, Bergamo, Italy
关键词
BRAF; immunohistochemistry; mutation; NRAS;
D O I
10.2217/MMT.14.27
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:5 / 8
页数:4
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共 20 条
[1]   MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study [J].
Ascierto, Paolo A. ;
Schadendorf, Dirk ;
Berking, Carola ;
Agarwala, Sanjiv S. ;
van Herpen, Carla M. L. ;
Queirolo, Paola ;
Blank, Christian U. ;
Hauschild, Axel ;
Beck, J. Thaddeus ;
St-Pierre, Annie ;
Niazi, Faiz ;
Wandel, Simon ;
Peters, Malte ;
Zubel, Angela ;
Dummer, Reinhard .
LANCET ONCOLOGY, 2013, 14 (03) :249-256
[2]   Tumor Homogeneity between Primary and Metastatic Sites for BRAF Status in Metastatic Melanoma Determined by Immunohistochemical and Molecular Testing [J].
Boursault, Lucile ;
Haddad, Veronique ;
Vergier, Beatrice ;
Cappellen, David ;
Verdon, Severine ;
Bellocq, Jean-Pierre ;
Jouary, Thomas ;
Merlio, Jean-Philippe .
PLOS ONE, 2013, 8 (08)
[3]   Immunohistochemical Analysis of BRAFV600E Expression of Primary and Metastatic Melanoma and Comparison With Mutation Status and Melanocyte Differentiation Antigens of Metastatic Lesions [J].
Busam, Klaus J. ;
Hedvat, Cyrus ;
Pulitzer, Melissa ;
von Deimling, Andreas ;
Jungbluth, Achim A. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2013, 37 (03) :413-420
[4]   Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation [J].
Chapman, Paul B. ;
Hauschild, Axel ;
Robert, Caroline ;
Haanen, John B. ;
Ascierto, Paolo ;
Larkin, James ;
Dummer, Reinhard ;
Garbe, Claus ;
Testori, Alessandro ;
Maio, Michele ;
Hogg, David ;
Lorigan, Paul ;
Lebbe, Celeste ;
Jouary, Thomas ;
Schadendorf, Dirk ;
Ribas, Antoni ;
O'Day, Steven J. ;
Sosman, Jeffrey A. ;
Kirkwood, John M. ;
Eggermont, Alexander M. M. ;
Dreno, Brigitte ;
Nolop, Keith ;
Li, Jiang ;
Nelson, Betty ;
Hou, Jeannie ;
Lee, Richard J. ;
Flaherty, Keith T. ;
McArthur, Grant A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) :2507-2516
[5]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[6]   Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma [J].
Feller, John K. ;
Yang, Shi ;
Mahalingam, Meera .
MODERN PATHOLOGY, 2013, 26 (03) :414-420
[7]   Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma [J].
Flaherty, Keith T. ;
Robert, Caroline ;
Hersey, Peter ;
Nathan, Paul ;
Garbe, Claus ;
Milhem, Mohammed ;
Demidov, Lev V. ;
Hassel, Jessica C. ;
Rutkowski, Piotr ;
Mohr, Peter ;
Dummer, Reinhard ;
Trefzer, Uwe ;
Larkin, James M. G. ;
Utikal, Jochen ;
Dreno, Brigitte ;
Nyakas, Marta ;
Middleton, Mark R. ;
Becker, Juergen C. ;
Casey, Michelle ;
Sherman, Laurie J. ;
Wu, Frank S. ;
Ouellet, Daniele ;
Martin, Anne-Marie ;
Patel, Kiran ;
Schadendorf, Dirk .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (02) :107-114
[8]   Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial [J].
Hauschild, Axel ;
Grob, Jean-Jacques ;
Demidov, Lev V. ;
Jouary, Thomas ;
Gutzmer, Ralf ;
Millward, Michael ;
Rutkowski, Piotr ;
Blank, Christian U. ;
Miller, Wilson H., Jr. ;
Kaempgen, Eckhart ;
Martin-Algarra, Salvador ;
Karaszewska, Boguslawa ;
Mauch, Cornelia ;
Chiarion-Sileni, Vanna ;
Martin, Anne-Marie ;
Swann, Suzanne ;
Haney, Patricia ;
Mirakhur, Beloo ;
Guckert, Mary E. ;
Goodman, Vicki ;
Chapman, Paul B. .
LANCET, 2012, 380 (9839) :358-365
[9]   NRAS mutation status is an independent prognostic factor in metastatic melanoma [J].
Jakob, John A. ;
Bassett, Roland L., Jr. ;
Ng, Chaan S. ;
Curry, Jonathan L. ;
Joseph, Richard W. ;
Alvarado, Gladys C. ;
Rohlfs, Michelle L. ;
Richard, Jessie ;
Gershenwald, Jeffrey E. ;
Kim, Kevin B. ;
Lazar, Alexander J. ;
Hwu, Patrick ;
Davies, Michael A. .
CANCER, 2012, 118 (16) :4014-4023
[10]   The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition [J].
Jiang, Xiaofeng ;
Zhou, Jun ;
Giobbie-Hurder, Anita ;
Wargo, Jennifer ;
Hodi, F. Stephen .
CLINICAL CANCER RESEARCH, 2013, 19 (03) :598-609