Histopathology of gastrointestinal neuroendocrine neoplasms

被引：47

作者：

Hirabayashi, Kenichi ^{[1
,2
]}

Zamboni, Giuseppe ^{[1
,3
]}

Nishi, Takayuki ^{[4
]}

Tanaka, Akira ^{[4
]}

Kajiwara, Hiroshi ^{[2
]}

Nakamura, Naoya ^{[2
]}

机构：

[1] Osped Sacro Cuore Don Calabria, Dept Pathol, Via Don Sempreboni 5, I-37024 Verona, Italy

[2] Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa, Japan

[3] Univ Verona, Dept Pathol, Verona, Italy

[4] Tokai Univ, Sch Med, Dept Surg, Isehara, Kanagawa, Japan

来源：

FRONTIERS IN ONCOLOGY | 2013年 / 3卷

关键词：

neuroendocrine neoplasm; carcinoid; neuroendocrine carcinoma; gastrointestinal tract; neuroendocrine marker;

D O I：

10.3389/fonc.2013.00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrointestinal neuroendocrine neoplasms (GI-NENs) arise from neuroendocrine cells distributed mainly in the mucosa and submucosa of the gastrointestinal tract. In 2010, the World Health Organization (WHO) classification of NENs of the digestive system was changed, categorizing these tumors as grade 1 neuroendocrine tumor (NET), grade-2NET, neuroendocrine carcinoma (large- or small-cell type), or mixed adenoneuroendocrine carcinoma (MANEC). Such a classification is based on the Ki-67 index and mitotic count in histological material. For the accurate pathological diagnosis and grading of NENs, it is important to clearly recognize the characteristic histological features of GI-NENs and to understand the correct method of counting Ki-67 and mitoses. In this review, we focus on the histopathological features of GI-NENs, particularly regarding biopsy and cytological diagnoses, neuroendocrine markers, genetic and molecular features, and the evaluation of the Ki-67 index and mitotic count. In addition, we will address the histological features of GI-NEN in specific organs.

引用

页数：11

共 89 条

[1]

Acs G, 2000, DIAGN CYTOPATHOL, V23, P183, DOI 10.1002/1097-0339(200009)23:3<183::AID-DC8>3.0.CO

[2]

2-4

[3] Immunohistologic analysis of gastrointestinal and pulmonary carcinoid tumors [J].