SYNTHESIS AND ASSAY OF HYBRID ANALOGS OF ARGIOTOXIN-636 AND PHILANTHOTOXIN-433 - GLUTAMATE-RECEPTOR ANTAGONISTS

被引：29

作者：

CHOI, SK

NAKANISHI, K

USHERWOOD, PNR

机构：

[1] UNIV NOTTINGHAM,DEPT LIFE SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

TETRAHEDRON | 1993年 / 49卷 / 26期

关键词：

ARGIOTOXIN-636; PHILANTHOTOXIN-433; GLUTAMATE RECEPTOR ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SELECTIVE ANTAGONISM; PHOTOAFFINITY LABEL; POLYAMINE-AMIDE TOXINS;

D O I：

10.1016/S0040-4020(01)87944-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on glutamate receptors are discussed.

引用

页码：5777 / 5790

页数：14

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