THEORY OF PULSE INSTABILITIES IN ELECTROPHYSIOLOGICAL MODELS OF EXCITABLE TISSUES

被引:30
作者
KARMA, A
LEVINE, H
ZOU, XQ
机构
[1] UNIV CALIF SAN DIEGO,INST NONLINEAR SCI,LA JOLLA,CA 92093
[2] UNIV CALIF SAN DIEGO,DEPT PHYS,LA JOLLA,CA 92093
来源
PHYSICA D | 1994年 / 73卷 / 1-2期
基金
美国国家科学基金会;
关键词
D O I
10.1016/0167-2789(94)90228-3
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
We develop a theoretical framework which allows, starting from multi-variable electrophysiological PDE models, to make ab initio quantitative predictions of the instability threshold and nonlinear dynamics of a pulse propagating in a ring of excitable tissue. This framework is based on the reduction of the PDE models to a single-front free-boundary problem in which the fast membrane-current variables are eliminated and only the dynamics of the slow relevant ones are retained. The solution of this free-boundary problem is in tum well approximated by a simple discrete map whose dimension D is equal to the number of slow membrane-current variables. This framework is applied to the Noble (D = 1) and Beeler-Reuter model (D = 3) of cardiac tissue and found to yield results in reasonably good quantitative agreement with PDE simulations. For the Beeler-Reuter model, the minimum period of stable propagation is found to depend sensitively on the dynamics of the calcium channel in a way which, together with the two-dimensional numerical simulations of Courtemanche and Winfree (Int. J. Bifurcation and Chaos 1 (1991) 431), strongly suggests that spiral breakup in this model occurs as a result of electrical alternans.
引用
收藏
页码:113 / 127
页数:15
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