High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

被引：13
作者：
Mostovaya, Iram M. [1 ]
Grooteman, Muriel P. C. [2 ,3 ]
Basile, Carlo [4 ]
Davenport, Andrew [5 ]
van Zuijdewijn, Camiel L. M. de Roij [2 ,3 ]
Wanner, Christoph [6 ]
Nube, Menso J. [2 ,3 ]
Blankestijn, Peter J. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Nephrol, Utrecht, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Nephrol, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res ICaR VU, Amsterdam, Netherlands
[4] Miulli Gen Hosp, Dept Med, Acquaviva Delle Fonti, Spain
[5] Royal Free Hosp, UCL Ctr Nephrol, London, England
[6] Univ Wurzburg, Dept Med, Div Nephrol, Wurzburg, Germany
来源：
CLINICAL KIDNEY JOURNAL | 2015年 / 8卷 / 04期
关键词：
convection volume; costs; hemodiafiltration; mortality; safety;
D O I：
10.1093/ckj/sfv040
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the 'dose' of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.
引用
收藏
页码：368 / 373
页数：6
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