SYNTHESIS AND ANTI-MICROBIAL STUDY OF OXADIAZOLYL INDAZOLES

被引：0
作者：
Kusanur, Raviraj A. [1 ]
Mahesh, R. [1 ]
机构：
[1] RV Coll Engn, Dept Chem, RV Vidyanikethana Post Mysore Rd, Bangalore, Karnataka, India
来源：
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH | 2013年 / 3卷 / 02期
关键词：
3-Aminoindazole; Suzuki reaction; Oxadiazoles; anti-microbial activity;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A rapid and efficient synthesis of substituted N-[(1,3,4-oxadiazol-2-yl) methyl]-4-fluoro-6-phenyl-1Hindazol-3-amines has been reported. The key intermediate is 2-(4-fluoro-6-phenyl-1H-indazol-3-ylamino) acetohydrazide (5), which has been obtained by series of reactions starting from cyclisation of 4-bromo-2, 6difluoro benzonitrile. All the newly synthesized oxadiazole derivatives were screened for their antimicrobial activity.
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页码：L6 / L10
页数：5
相关论文
共 12 条
  • [1] CASMAN EP, 1947, AM J CLIN PATHOL, V17, P281
  • [2] Pharmacological properties of indazole derivatives:: Recent developments
    Cerecetto, H
    Gerpe, A
    González, M
    Arán, VJ
    de Ocáriz, CO
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (10) : 869 - 878
  • [3] Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000-2012
    de Oliveira, Cledualdo Soares
    Lira, Bruno Freitas
    Barbosa-Filho, Jose Maria
    Fernandez Lorenzo, Jorge Goncalo
    de Athayde-Filho, Petronio Filgueiras
    [J]. MOLECULES, 2012, 17 (09) : 10192 - 10231
  • [4] QUINAZOLINEACETIC ACIDS AND RELATED ANALOGS AS ALDOSE REDUCTASE INHIBITORS
    MALAMAS, MS
    MILLEN, J
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (04) : 1492 - 1503
  • [5] Nagaraj K. C Chaluvaraju, 2011, INT J PHARM PHARM SC, V3
  • [6] Patel Navin B, 2010, Sci Pharm, V78, P171, DOI 10.3797/scipharm.0912-16
  • [7] α-Oxoketene dithioacetals mediated heteroaromatic annulation protocol for benzoheterocycles:: an efficient regiocontrolled synthesis of highly substituted and annulated indazoles
    Peruncheralathan, S
    Khan, TA
    Ila, H
    Junjappa, H
    [J]. TETRAHEDRON, 2004, 60 (15) : 3457 - 3464
  • [8] Recent advances in the chemistry of indazoles
    Schmidt, Andreas
    Beutler, Ariane
    Snovvdovych, Bohdan
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (24) : 4073 - 4095
  • [9] Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity
    Stocks, MJ
    Barber, S
    Ford, R
    Leroux, F
    St-Gallay, S
    Teague, S
    Xue, YF
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (14) : 3459 - 3462
  • [10] Temesgen Zelalem, 2008, Ther Clin Risk Manag, V4, P493
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