SENNOSIDES AND ALOIN DO NOT PROMOTE DIMETHYLHYDRAZINE-INDUCED COLORECTAL TUMORS IN MICE

被引：13
|
作者：
SIEGERS, CP [1 ]
SIEMERS, J [1 ]
BARETTON, G [1 ]
机构：
[1] MED UNIV LUBECK,INST PATHOL,D-23562 LUBECK,GERMANY
来源：
PHARMACOLOGY | 1993年 / 47卷
关键词：
ALOIN; SENNOSIDES; DIMETHYLHYDRAZINE; COLORECTAL TUMORS; TUMOR PROMOTION;
D O I：
10.1159/000139859
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrotoxicity were observed.
引用
收藏
页码：205 / 208
页数：4
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