A SYSTEMATIC EVALUATION OF THE INHIBITION OF HIV-1 PROTEASE BY ITS C-TERMINAL AND N-TERMINAL PEPTIDES

被引：31

作者：

FRANCISKOVICH, J

HOUSEMAN, K

MUELLER, R

CHMIELEWSKI, J

机构：

[1] PURDUE UNIV, DEPT CHEM, W LAFAYETTE, IN 47907 USA

[2] SEARLE RES & DEV, SKOKIE, IL 60022 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81271-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

C- and N-terminal peptides of varying lengths corresponding to the dimerization interface of the retroviral protease of the human immunodeficiency virus-1 (HIV-1 protease) have been synthesized and evaluated as inhibitors of HIV-1 protease activity.

引用

页码：765 / 768

页数：4

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