Comparison of the New Low-Cost Nonvalved Glaucoma Drainage Device with Ahmed Glaucoma Valve in Refractory Pediatric Glaucoma in Indian Eyes

Purpose: To compare outcomes of a nonvalved glaucoma drainage device (the Aurolab aqueous drainage device [AADI] with a valved glaucoma drainage device (the Ahmed glaucoma valve [AGV]) in refractory pediatric glaucoma. Design: Retrospective interventional case series. Participants: One hundred sixteen eyes of 97 children with refractory pediatric glaucoma. Methods: Children (<= 16 years) treated with drainage implants from January 2007 through December 2016 with a minimum follow-up of 6 months (operated by a single surgeon) were included. Success was defined as intraocular pressure (IOP) >= 6 mmHg or <= 21 mmHg (complete without antiglaucoma medications [AGMs] and qualified with AGM); repeat glaucoma surgery or loss of light perception was failure. Main Outcome Measures: Comparison of success rates and complications with AADI (350 mm(2)) and silicone AGV (models FP7 [182-mm(2) surface area] and FP8 [102-mm(2) surface area]) implantation. Results: Outcomes of 116 eyes of 97 children (AADI, 36 eyes; AGV, 85 eyes; FP7, n = 14; FP8, n = 72) were analyzed. Median follow-up for AADI was 16.8 months (interquartile range [IQR], 11.7-24.5 months) and for AGV was 27 months (IQR, 15.3-52.3 months). Preoperative parameters (age, IOP, number of AGMs) were similar in both groups except number of previous nonglaucoma surgeries, which were significantly more in AADI (P = 0.05). Qualified success was similar (P = 0.81) in both groups, 91% and 88% at 1 year and 81% and 84% at 3 years with AADI and AGV, respectively. With AADI, the complete success was significantly more (41.8% vs.13.7%; P < 0.005). The postoperative mean IOP (12.6 +/- 5.5 mmHg vs. 17.6 +/- 6.8 mmHg; P = 0.001), median number of AGMs (1 [IQR, 0-2] vs. 2 [IQR, 1-3]; P < 0.001), and hypertensive phase (16.5% [n = 7] vs. 40% [n = 34]; P = 0.02) were significantly less in AADI compared with AGV. Transient complications (AADI, 30.5% [n = 11/36] vs. AGV, 21.1 % [n = 18/85]; P = 0.26), sight-threatening complications (AADI, 13.9% [n = 5/36) vs. AGV, 7% [n = 6/85]; P = 0.22), and complications needing intervention (AADI, 19.4% [n = 7/36] vs. AGV, 14.1% [n = 12/85]; P = 0.46) were similar in both groups. Conclusions: In refractory pediatric glaucoma, both AGV and AADI showed similar qualified success and complication rates at 1 and 3 years. However, the AADI showed greater complete success, better IOP control, less need for AGM, and lesser incidence of an hypertensive phase. (C) 2018 by the American Academy of Ophthalmology