SELECTIVE ACCUMULATION OF MPP+ IN THE SUBSTANTIA NIGRA - A KEY TO NEUROTOXICITY

被引:159
作者
IRWIN, I [1 ]
LANGSTON, JW [1 ]
机构
[1] SANTA CLARA VALLEY MED CTR,SAN JOSE,CA 95128
关键词
D O I
10.1016/0024-3205(85)90060-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:207 / 212
页数:6
相关论文
共 13 条
[1]  
BALLARD PA, NEUROLOGY NY
[2]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[3]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[4]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[5]   CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].
LANGSTON, JW ;
BALLARD, P ;
TETRUD, JW ;
IRWIN, I .
SCIENCE, 1983, 219 (4587) :979-980
[6]   PARGYLINE PREVENTS MPTP-INDUCED PARKINSONISM IN PRIMATES [J].
LANGSTON, JW ;
IRWIN, I ;
LANGSTON, EB ;
FORNO, LS .
SCIENCE, 1984, 225 (4669) :1480-1482
[7]   1-METHYL-4-PHENYLPYRIDINIUM ION (MPP+) - IDENTIFICATION OF A METABOLITE OF MPTP, A TOXIN SELECTIVE TO THE SUBSTANTIA NIGRA [J].
LANGSTON, JW ;
IRWIN, I ;
LANGSTON, EB ;
FORNO, LS .
NEUROSCIENCE LETTERS, 1984, 48 (01) :87-92
[8]  
LANGSTON JW, 1984, BR RES, V292, P391
[9]  
LYDEN A, 1983, ACTA PHARMACOL TOX, V53, P429
[10]  
LYLE RE, 1962, TETRAHEDRON LETT, V13, P553