tRNA-Derived Short Non-coding RNA as Interacting Partners of Argonaute Proteins

被引:66
作者
Shigematsu, Megumi [1 ]
Kirino, Yohei [1 ]
机构
[1] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Computat Med Ctr, Philadelphia, PA 19107 USA
来源
GENE REGULATION AND SYSTEMS BIOLOGY | 2015年 / 9卷
关键词
transfer RNA; tRNA fragment; microRNA; Argonaute family protein; AGO protein;
D O I
10.4137/GRSB.S29411
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The advent of next-generation sequencing technologies has not only accelerated findings on various novel non-coding RNA (ncRNA) species but also led to the revision of the biological significance and versatility of fundamental RNA species with canonical function, such as transfer RNAs (tRNAs). Although tRNAs are best known as adapter components of translational machinery, recent studies suggest that tRNAs are not always end products but can further serve as a source for short ncRNAs. In many organisms, various tRNA-derived ncRNA species are produced from mature tRNAs or their precursor transcripts as functional molecules involved in various biological processes beyond translation. In this review, we focus on the tRNA-derived ncRNAs associated with Argonaute proteins and summarize recent studies on their conceivable biogenesis factors and on their emerging roles in gene expression regulation as regulatory RNAs.
引用
收藏
页码:27 / 33
页数:7
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