PARVOVIRUS B19 INFECTION AND HEMATOPOIESIS

被引:86
作者
BROWN, KE
YOUNG, NS
机构
[1] Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, MD 20892-1652, Bldg. 10/Room 7CZ18
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0268-960X(95)90023-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Parvovirus B19, the only known human pathogenic parvovirus, is highly tropic to human bone marrow and replicates only in erythroid progenitor cells. The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen). In individuals with underlying hemolytic disorders, infection with parvovirus B19 is the primary cause of transient aplastic crisis (TAG). In immunocompromised patients, persistent B19 infection may develop that manifests as pure red cell aplasia and chronic anemia, B19 infection in utero can result in fetal death, hydrops fetalis, or congenital anemia. Diagnosis is based on examination of the bone marrow and B19 virological studies. Treatment of persistent infection with immunoglobulin leads to a rapid marked resolution of the anemia.
引用
收藏
页码:176 / 182
页数:7
相关论文
共 30 条
[1]  
ABKOWITZ JL, 1993, CLIN RES, V41, pA393
[2]   EXPERIMENTAL PARVOVIRAL INFECTION IN HUMANS [J].
ANDERSON, MJ ;
HIGGINS, PG ;
DAVIS, LR ;
WILLMAN, JS ;
JONES, SE ;
KIDD, IM ;
PATTISON, JR ;
TYRRELL, DAJ .
JOURNAL OF INFECTIOUS DISEASES, 1985, 152 (02) :257-265
[3]  
[Anonymous], 1990, BRIT MED J, V300, P1166
[4]   CANDIDATE RECOMBINANT VACCINE FOR HUMAN B19-PARVOVIRUS [J].
BANSAL, GP ;
HATFIELD, JA ;
DUNN, FE ;
KRAMER, AA ;
BRADY, F ;
RIGGIN, CH ;
COLLETT, MS ;
YOSHIMOTO, K ;
KAJIGAYA, S ;
YOUNG, NS .
JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (05) :1034-1044
[5]   RESISTANCE TO PARVOVIRUS B19 INFECTION DUE TO LACK OF VIRUS RECEPTOR (ERYTHROCYTE P-ANTIGEN) [J].
BROWN, KE ;
HIBBS, JR ;
GALLINELLA, G ;
ANDERSON, SM ;
LEHMAN, ED ;
MCCARTHY, P ;
YOUNG, NS .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (17) :1192-1196
[6]   CONGENITAL ANEMIA AFTER TRANSPLACENTAL B19 PARVOVIRUS INFECTION [J].
BROWN, KE ;
GREEN, SW ;
DEMAYOLO, JA ;
BELLANTI, JA ;
SMITH, SD ;
SMITH, TJ ;
YOUNG, NS .
LANCET, 1994, 343 (8902) :895-896
[7]   ERYTHROCYTE-P ANTIGEN - CELLULAR RECEPTOR FOR B19 PARVOVIRUS [J].
BROWN, KE ;
ANDERSON, SM ;
YOUNG, NS .
SCIENCE, 1993, 262 (5130) :114-117
[8]   MOLECULAR, CELLULAR AND CLINICAL ASPECTS OF PARVOVIRUS B19 INFECTION [J].
BROWN, KE ;
YOUNG, NS ;
LIU, JM .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 1994, 16 (01) :1-31
[9]   DIAGNOSTIC ASSAYS WITH MONOCLONAL-ANTIBODIES FOR THE HUMAN-SERUM PARVOVIRUS-LIKE VIRUS (SPLV) [J].
COHEN, BJ ;
MORTIMER, PP ;
PEREIRA, MS .
JOURNAL OF HYGIENE, 1983, 91 (01) :113-&
[10]   PERSISTENT B19 PARVOVIRUS INFECTION IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) - A TREATABLE CAUSE OF ANEMIA IN AIDS [J].
FRICKHOFEN, N ;
ABKOWITZ, JL ;
SAFFORD, M ;
BERRY, JM ;
ANTUNEZDEMAYOLO, J ;
ASTROW, A ;
COHEN, R ;
HALPERIN, I ;
KING, L ;
MINTZER, D ;
COHEN, B ;
YOUNG, NS .
ANNALS OF INTERNAL MEDICINE, 1990, 113 (12) :926-933